Poster at 2020 AAPS PharmSci 360 Meeting
SEKISUI XenoTech will have a poster at this year’s virtual AAPS PharmSci 360 meeting from Oct. 26th-Nov. 5th, 2020.
The poster is entitled “Effects of Monocyte Chemoattractant Protein-1, Macrophage Inflammatory Protein-1α and Interferon-α2a on P450 Enzymes in Human Hepatocytes in Vitro” and is authored by Maciej Czerwiński, Krystal Gilligan, Kevin Westland, and Brian W. Ogilvie.
Some immunomodulatory drugs stimulate the innate immune system to release cytokines that may change expression of drug-metabolizing enzymes. In drug development, regulation of multiple pro- and anti-inflammatory cytokines by Toll-like receptors (TLR) has gained attention in parallel to targeting the therapeutic potential of these receptors (Hennessy et al., 2010; Patel et al., 2014). In a previous study, tilsotolimod, an agonist of TLR9 designed to enhance T-cell responses to tumor antigens, stimulated release of cytokines in human blood (Tarantino et al., 2018). The aim of this study was to establish whether MCP-1, MIP-1α or IFN-α2a were responsible for the effects of tilsotolimod-stimulated plasma on CYP1A2 and CYP2B6 mRNA and enzyme activity levels…