Drug transport studies use regulatory guidance-compliant test systems to investigate a compound’s potential to operate as a substrate or inhibitor of known uptake (SLC) and efflux (ABC) transporters, precipitating a potential drug-drug interaction. For more information about these services, visit our Drug Transport contract service page.
What are drug transporters? Drug transporters are membrane-bound proteins that assist in the movement of drugs into or out of...
A recap of some of the important and promising research that was presented at the Transporters in Drug Discovery and Development symposium...
With over 3500 respondents, only 4% of respondents said they had never experienced any repercussions from postponing these studies...
Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...
In its most recent in vitro drug interaction guidance update, the US Food and Drug Administration (FDA) emphasized harmony with the...
1. Collect high-quality data to make informed, confident go/no go decisions for moving your drug candidate forward If you need...
Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...
Beyond the need for evidence that a drug works, Food and Drug Administration (FDA) and other regulatory bodies around the...
Though there is no ‘roadmap’ spelling out required studies to achieve regulatory approval for clinical entry, a drug candidate’s metabolism...
Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...
Generally, a drug’s effects on enzyme and transporter activity are examined independently in a drug development program, but what if...
We’re pleased to announce that our scientists’ ongoing dedication to enhancing our processes and discovering new efficiencies without sacrificing quality...
Dr. Ogilvie’s presentation discusses critical literature and case studies which have been published following the FDA’s 2017 guidance revision, and covered...
Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...
The Pharmaceutical and BioScience Society (PBSS) hosted the workshop “Drug-Drug Interactions: Update on Risk Assessment, Clinical Evaluation and Regulatory Requirements” on October...
That is the question. . . Knowing the answer may save you time and money Good Laboratory Practices (GLP) are...
Brian Ogilvie, Ph.D., Vice President of Scientific Consulting at XenoTech, presented a case study on the importance of the hepatic OCT1...
Transporters are membrane-bound proteins that govern the passage of drugs into and out of cells. These gatekeeper proteins can be...
The American Association of Pharmaceutical Scientists (AAPS) and U.S. Food and Drug Administration (FDA) co-sponsored the workshop “Drug Transporters in ADME:...
Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...
The clinically-relevant drug-drug interaction (DDI) between the dyslipidemia drug gemfibrozil and the antidiabetic repaglinide is well-documented throughout the literature. In...
The University of Rhode Island College of Pharmacy’s 5th Annual Transporters in Drug Discovery and Development: Driving Knowledge from Laboratory...
Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...
XenoTech scientists published a paper in Drug Metabolism and Disposition evaluating Ketoconazole and its alternative clinical CYP3A4-5 inhibitors as inhibitors of drug...
The International Transporter Consortium (ITC) issued 7 papers in the July 2013 issue of Clinical Pharmacology & Therapeutics. These 7...