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Webinars

Reactive Metabolite Detection Studies: Cysteine Trapping

Presenter: Miki Fujishima, Manager in Business Development at the Drug Development Solutions Center in Tokai, Japan. Abstract: Drug-induced liver injury (DILI) is caused by various...
Webinars

The Role of In Vitro Assays in Selecting the Right Species for Your Small Molecule Program

Presenters: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at XenoTech and Scott Boley, Ph.D., DABT, Senior Vice President of Research at Sinclair Research...
Webinars

In Vitro Cholestatic DILI & Mitochondrial Toxicity Studies to Assess Hepatotoxicity

Drug-Induced Liver Injury (DILI) incidents account for more than 10% of all cases of acute liver failure, posing a major clinical and regulatory challenge. While the cause of DILI is multifactorial and difficult to predict, there are known mechanisms...
Blog

Toxicokinetic (TK) Analysis for Preclinical Drug Development

The main goal of preclinical toxicokinetic (TK) studies is to establish a correlation between a candidate compound’s concentration or dose...

Scientific Posters

Toxicity evaluation by high content analysis of 3D cultured primary human hepatocytes

Full Title Toxicity evaluation by high content analysis of 3D cultured primary human hepatocytes Authors Toshimasa Ito, Kazuhiro Fujimoto, Ryo Fujino, Masato Kobayashi, Miki Fujishima,...
Blog

What is DMPK and how does it fit into drug development?

Drug metabolism and pharmacokinetics (DMPK) is a core discipline in drug development that considers the biotransformation of a drug compound...

Blog

Meet the Scientist: Pallavi Limaye

We have welcomed a new consultant to the team! Dr. Pallavi Limaye now serves as a Director in the Scientific...

Blog

ADME and Drug-Drug Interactions for the Toxicologist

Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...

Blog

In Vitro Evaluation of Drug-Drug Interaction (DDI) Potential

In its most recent in vitro drug interaction guidance update, the US Food and Drug Administration (FDA) emphasized harmony with the...

Blog

Four ways to optimize preclinical in vitro data to mitigate risk of late-stage clinical failure

1. Collect high-quality data to make informed, confident go/no go decisions for moving your drug candidate forward If you need...

Blog

How can in vitro and in vivo studies help me understand my drug’s clearance?

Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...

Blog

What You Need to Know About Micro-Autoradiography (mARG) Distribution Studies

In vivo determination of drug localization in tissue can be uniquely informative to drug developers investigating distribution within the context of...

Blog

What In Vitro Metabolism and DDI Studies Do I Actually Need?

Though there is no ‘roadmap’ spelling out required studies to achieve regulatory approval for clinical entry, a drug candidate’s metabolism...

Blog

Mass Balance Studies: What You Need and Why You Need It

In vivo mass balance studies are an important element of nonclinical drug development, to inform first in-human (FIH) studies and to...

Blog

Why You Need QWBA for Human Radiolabeled ADME Studies

A quantitative whole body autoradiography (QWBA) study provides data required for Human Radiolabeled ADME Studies1. Quantitative whole body autoradiography (QWBA) is an in...

Blog

How to Choose the Right Test Systems for Your DMPK Studies

Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...

Scientific Posters

Human mAb stability and cytotoxicity in rat hepatocytes with a surrogate peptide approach

Evaluating stability and cytotoxicity of human monoclonal antibody in cultured rat hepatocytes with a surrogate peptide approach Presented at the 12th International ISSX Meeting in Portland...
Scientific Posters

Human monoclonal antibody stability in rat cell cultures using surrogate peptide LC-MS/MS

Evaluating stability of human monoclonal antibody in rat cell cultures using a surrogate peptide LC-MS/MS approach Presented at the 67th ASMS Conference on Mass Spectrometry &...
Blog

In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis

Why do induction studies? Induction potential is an important piece of the drug-drug interaction (DDI) component of an IND submission. Simply put, we...

Blog

Minding Your Binding: Plasma Protein Binding Potential Study Now Available at Our US Labs

While liver and intestine are important in ADME, behavior in blood is also crucial. When an orally administered drug or...

Blog

Studies in Japan: Easier & More Beneficial than You Might Think

XenoTech is well-known to pharmaceutical companies and toxicology academics alike for unparalleled experience in quality in vitro ADME/DMPK/DDI studies and complementary products,...

Blog

Can Interactions Between Therapeutic Proteins and Small Molecule Drugs Be Evaluated In Vitro?

The mechanisms of clearance for small molecule drugs and therapeutic proteins are fundamentally distinct and therefore therapeutic proteins are generally not...

Blog

Important Considerations for the Conduct of In Vitro Drug Transporter Assays

Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...

Blog

To GLP or not to GLP?

That is the question. . . Knowing the answer may save you time and money Good Laboratory Practices (GLP) are...

Blog

Choosing a Relevant Small Animal Model for Pharmacokinetic or Toxicity Studies

Choosing the most suitable small animal model is crucial for pharmacokinetic and/or toxicology studies in order to get usable, relevant data. Due to potential...

Scientific Posters

Evaluation method for mitochondrial toxicity using Crabtree effect

Full Title Evaluation method for mitochondrial toxicity using Crabtree effect Abstract Mitochondria plays a crucial role in living organisms, one of which being the synthesis...
Scientific Posters

Comparative Investigation of Benzoapyrene, Procaine and Nevirapine Metabolism in Human Hepatocytes

Full Title Comparative Investigation of Benzoapyrene, Procaine and Nevirapine Metabolism in Human Hepatocytes Abstract Skin metabolism is an important contributor to the safety and efficacy...
Scientific Posters

The Impact of Various Solvents and Solvent Concentrations on In Vitro Enzyme Induction Assessment

Full Title The Impact of Various Solvents and Solvent Concentrations on In Vitro Enzyme Induction Assessment Abstract Induction of cytochrome P450 (CYP) enzymes is one...
Scientific Posters

Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents

Full Title Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents Abstract Drug induced liver injury (DILI)...
Scientific Posters

The Use of Pooled Plated Cryopreserved Human Hepatocytes for the Determination of Metabolic Clearance, CYP Induction, and Uptake Transporter Studies

Full Title The Use of Pooled Plated Cryopreserved Human Hepatocytes for the Determination of Metabolic Clearance, CYP Induction, and Uptake Transporter Studies Abstract During early...
Publications

Catechol and aldehyde moieties of 3,4-dihydroxyphenylacetaldehyde contribute to tyrosine hydroxylase inhibition and neurotoxicity

Lydia M. Vermeer , Virginia R. Florang , Jonathan A. Doorn Parkinson’s disease (PD) is a progressive neurodegenerative disorder which leads to the selective loss...
Scientific Posters

In vitro inhibition and induction of human liver cytochrome P450 enzymes by NTBC and its metabolism in human liver microsomes

In vitro inhibition and induction ofHuman liver cytochrome P450 enzymes by NTBC and its metabolism in human liver microsomes 2-(2-Nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC, also known as...
Scientific Posters

The Use of Immortalized Hepatocytes in Induction Studies

Abstract Primary cultures of human hepatocytes are widely used to evaluate the cytochrome P450 (CYP) enzyme-inducing potential and/or toxicity of drug candidates. However, the availability...