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Scientific Posters

Effects of Monocyte Chemoattractant Protein-1, Macrophage Inflammatory Protein-1α and Interferon-α2a on P450 Enzymes in Human Hepatocytes in Vitro

Some immunomodulatory drugs, such as tilsotolimod, stimulate the innate immune system to release cytokines that may change expression of drug-metabolizing enzymes. In drug development, regulation of multiple pro- and anti-inflammatory cytokines by Toll-like receptors (TLR) has gained attention in parallel to targeting the therapeutic potential of these receptors. The aim of this study was to establish whether MCP-1, MIP-1α or IFN-α2a were responsible for the effects of tilsotolimod-stimulated plasma on CYP1A2 and CYP2B6 mRNA and enzyme activity levels...

Comparison Between the Final US FDA, Japan PMDA and EMA In Vitro DDI Guidance

Comparison Between the Final US FDA (2020), the Final Japan PMDA (2018), and Final EMA (2013) In Vitro DDI Guidance Documents: Are We Finally Harmonized?...

The evaluation of induction and inhibition potency of various drugs on CYP3A4 and OATP1B1/1B3

Presented at the 34th JSSX Annual Meeting in Tsukuba, Japan Authors Ryota Takeuchi, Rena Kusano, Tomoko Sasai, Takami Sarashina, Ryo Fujino, Kenta Hashizume  Drug Development...

CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...

CYP1A2 enzyme localization in normal and diseased pediatric livers

Presented at the 55th Congress of European Societies of Toxicology (EUROTOX 2019) in Helsinki, Finland Full Poster Title “CYP1A2 Enzyme Activity and Protein Abundance In Normal...

Human mAb stability and cytotoxicity in rat hepatocytes with a surrogate peptide approach

Evaluating stability and cytotoxicity ofHuman monoclonal antibody in cultured rat hepatocytes with a surrogate peptide approach Presented at the 12th International ISSX Meeting in Portland,...

Human monoclonal antibody stability in rat cell cultures using surrogate peptide LC-MS/MS

Evaluating stability ofHuman monoclonal antibody in rat cell cultures using a surrogate peptide LC-MS/MS approach Presented at the 67th ASMS Conference on Mass Spectrometry &...

An assessment of in vitro inhibition of CYPs, UGTs and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides

Presented at the 2019 Marbach Castle Drug-Drug Interaction Workshop in Germany by Dr. Brian W. Ogilvie. Authors The poster presented information based on the publication:...

Patterns of hyaluronan deposition in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...

Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis

Presented at the 2019 AASLD Liver Meeting in San Francisco, CA Authors Dr. Maciej Czerwinski1, Jordan Surgnier2, Dr. Sarah E. Tague3 and Dr. Michele T....