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The evaluation of induction and inhibition potency of various drugs on CYP3A4 and OATP1B1/1B3

  • Published on December 10, 2019
  • Drug Transporters
  • Enzyme Induction
  • Enzyme Inhibition
  • Scientific Posters

Presented at the 34th JSSX Annual Meeting in Tsukuba, Japan

Authors

Ryota Takeuchi, Rena Kusano, Tomoko Sasai, Takami Sarashina, Ryo Fujino, Kenta Hashizume 
Drug Development Solutions Center, Sekisui Medical Co., Ltd.
2117 Muramatsu, Tokai, Ibaraki 319-1182, Japan

Abstract

It is well known that the drug-mediated induction of cytochrome P450s (CYPs) has an important role in clinical drug-drug interactions (DDI). In addition, the DDI guidance issued by the U.S. Food and Drug Administration (FDA) suggests evaluating the induction potency of drugs on transporters, however, the evaluation is not performed frequently. Thus, we evaluated the induction and inhibition potency of CYP3A4 and organic anion transporting polypeptide (OATP) 1B1/1B3, that are induced by the same nuclear receptor, using various drugs related to DDI of CYP3A4 and OATP1B1/1B3…

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