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Author: Dr. Joanna Barbara

In Vitro Evaluation of Drug-Drug Interaction (DDI) Potential

In its most recent in vitro drug interaction guidance update, the US Food and Drug Administration (FDA) emphasized harmony with the...

How can in vitro and in vivo studies help me understand my drug’s clearance?

Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...

In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis

Why do induction studies? Induction potential is an important piece of the drug-drug interaction (DDI) component of an IND submission. Simply put, we...

Minding Your Binding: Plasma Protein Binding Potential Study Now Available at Our US and Japan Labs

While liver and intestine are important in ADME, behavior in blood is also crucial. When an orally administered drug or...

Challenges & Solutions in Today’s In Vitro Transporter Research

Transporters are membrane-bound proteins that govern the passage of drugs into and out of cells. These gatekeeper proteins can be...

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