Drug Metabolism
Recombinant CYP Bactosomes: Versatile Formats for Many ADME Applications
Originally published in tebu-bio’s Being Bioreactive. To purchase recombinant CYPs in the EU, please visit tebu-bio’s website. For North American orders, please follow...
What To Do with Microsome Stable Low Turnover Compounds
Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol) can be a challenge for ADME scientists. These in...
HepatoSure Hepatocytes: The Largest Donor Pool For Your DMPK Applications
Pooled human hepatocytes can complement a selection of hepatocytes from various species for metabolite profiling, species comparison and evaluation of potential human-specific metabolites. HepatoSure® is the...
Cold Storage Solution Linked to Lower AO, XO Activity
At the time of organ recovery, human livers that have been donated for research are flushed with an ice-cold perfusion...
Considerations When Studying Esterase Activities in the Intestine
The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...
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