March 2018

Choosing a Relevant Small Animal Model for Pharmacokinetic or Toxicity Studies

Author:  Dr. Chris Bohl
Posted:  01 March 2018

Choosing the most suitable small animal model is crucial for pharmacokinetic and/or toxicology studies in order to get usable, relevant data. Due to potential species-dependent variability in candidate drug metabolism, the decision of which small animal model to utilize may not always be obvious.
 
Sekisui XenoTech can generate data to help you identify a suitable small animal model by carrying out species comparison studies with your drug candidate. These studies can be carried out by analyzing and comparing incubations using a wide array of matrices from different species and analytical methods that have been produced and developed at Sekisui XenoTech. While the most common species/strains are listed below, evaluation of other animal models can be offered to meet the specific needs of your study.
 
Common species used for comparison: CD1 Mouse, Sprague-Dawley Rat, Beagle Dog, Cynomolgus Monkey, and Human.
Common Matrices: Microsomes, Hepatocytes, recombinant CYPs, etc.
Common Analytical Methods: LC-MS/MS, LC/UV, LC/radio-detection, etc. The most definitive species comparison is metabolite characterization with LC-MS/MS
 
Contact us to learn more or request a species comparison study

Mass-chromatograms-showing-marked-species-differences-drug.jpg

Mass chromatograms showing marked species differences for a drug incubated with rat, monkey or human liver microsomes

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