May 2018

AAPS-FDA Drug Transporters in ADME Workshop Recap

Author: Greg Loewen, Michael Millhollen Posted: 30 May 2018

The AAPS and FDA co-sponsored the workshop “Drug Transporters in ADME: From the Bench to the Bedside.” There were 26 presentations covering numerous aspects of transporter science as well as poster sessions...

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NADPH RapidStart regeneration system for extended metabolism

Author: Isabelle Nobiron, tebu-bio Posted: 30 May 2018

A post from our EU partner, tebu-bio, on NADPH regeneration for ADME-Tox studies using recombinant CYPs (incl. bactosomes) or cellular fractions (Microsomes, S9)...

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In Vitro DDI Regulatory Guidance Reference Poster

Author: Michael Millhollen Posted: 29 May 2018

Download Sekisui XenoTech’s poster outlining the current FDA, EMA & PMDA guidance experimental details, equations, cut-off values, etc. for in vitro drug-drug interaction studies...

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Maximize Metabolic Activities by Limiting Hepatocyte Cryoinjury

Author: Dr. Chris Bohl, Michael Millhollen Posted: 01 May 2018

Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. However, utilizing a single-freeze method for pooling donors is shown to preserve higher metabolic activity...

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