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No-Cost, On-Demand Primary Human Hepatocyte Pooling Using CryostaX Pellets

CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows scientists to easily pool primary hepatocytes from different donors, with up to 20 donors in a standard vial, without inflicting a second cryopreservation step on the cells.

This unmatched solution allows SEKISUI XenoTech to quickly combine individual donors’ hepatocytes in any combination to create on-demand, custom pools without any additional costs. Since each individual is extensively characterized, custom pools can be designed based on donor demographics, medical histories, genotyping, metabolic activity and more. Common options include:

  • Specific Enzyme Activity
  • Assured Minimum Yield (AMY)
  • Pool Size
  • BMI
  • Disease State
  • Age, Ethnicity &/or Gender
  • Alcohol, Tobacco &/or Drug Use
  • Serologies

Because designing and producing custom CryostaX® human hepatocyte pools does not demand thawing vials from multiple lots, physically pooling the lots, and then re-cryopreserving the hepatocytes; custom CryostaX® pools also maintain the highest possible metabolism activity from only having undergone a single cryopreservation, reducing cryoinjury to the cells.

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About the Authors

Michael Millhollen received his bachelor's degree in Visual Communications from the University of Kansas and has over 20 years of experience in marketing and communications. As Global Marketing Manager, he is dedicated to the objective of sharing SEKISUI XenoTech’s scientific expertise and knowledge with scientists around the world.
Dr. Chris Bohl received his PhD from the School of Biological Sciences from the University of Nebraska – Lincoln and has been with SEKISUI XenoTech since 2014, first operating as a research scientist before becoming the Senior Manager of Technical Support for Products. Chris provides valuable guidance to scientists seeking to choose the correct test system, troubleshoot difficulties and much more.

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