2019 HRA ISSX Meeeting

2019 HRA ISSX Meeeting

Monday, July 29, 2019

15th Annual Hepatocyte Research Association Assembly at ISSX 2019

 
Where:
Ballroom 252-253
Portland Convention Center
 
When:
5:30-9:00 PM
Monday, July 29th 2019
 
What:
“Perspectives on comparisons of different in vitro hepatic models”
Three presentations will follow dinner and Welcome Reception, discussing latest methods and research for use of hepatic models in drug development. Following the presentations will be an expert panel discussion with Q&A. Free to attend, the event is a great chance to network and discuss latest development in industry and research.
 
Presentations:
“Engineering phenotypically stable hepatocyte culture platforms for drug development”
Dr. Salman Khetani received his MS and PhD degrees in bioengineering from University of California at San Diego (UCSD). He was a Jacobs fellow and National Science Foundation graduate fellow at UCSD. After postdoctoral research at MIT in the laboratory of Professor Sangeeta Bhatia, Dr. Khetani co-founded and directed research at Hepregen Corporation to commercialize his bioengineered liver inventions. In 2011, Dr. Khetani returned to academia, first to Colorado State University and then in 2015 as Associate Professor of Bioengineering at the University of Illinois at Chicago, where his ‘Microfabricated Tissue Models’ laboratory designs and implements novel engineered tissues for drug screening, investigations of human diseases, and regenerative medicine.
 
IVIVE of hepatic uptake clearance using transporter-expressing cells and relative expression factor”
Dr. Jashvant Unadkat received his B.Pharm from the University of London, his Ph.D. from the University of Manchester and his postdoctoral training at the University of California at San Francisco. Currently he is the Milo Gibaldi Endowed Professor at the School of Pharmacy, University of Washington, Seattle. Dr. Unadkat studies the mechanisms of transport and metabolism of drugs, including during pregnancy. He is a fellow of AAAS, AAPS, JSSX, and the founding co-chair (1999-2001) of the focus group of AAPS on Drug Transport and Uptake. Dr. Unadkat created and leads the UW Research Affiliates Program on Transporters (UWRAPT), funded by pharmaceutical companies and UWPKDAP, a NIDA funded Program Project grant on drug disposition during pregnancy.
 
Assessment of therapeutic protein drug interaction with small molecules using primary human hepatocyte spheroids
Dr. Jing Wang received her undergraduate and graduate training at the University of Louisville. Her research interests include DDI, IVIVC, MPS and new models and tools for better translation from in vitro to in vivo DMPK investigation. She is currently a scientist in the Department of DMPK at Denali Therapeutics. She ADME strategies as well as designs, analyzes ADME and transport properties of drug candidates to provide DMPK guidance for project teams. Prior to that she spent four years at Genentech in the in vitro DMPK group. At Genentech, she was a DMPK team lead responsible for assessing ADME properties of compounds to support clinical candidate selection and regulatory filing. She was also responsible for developing hepatocyte co-cultured model to study drug metabolism and DDI.
 
Register here to attend, dinner provided for the first 200 registrants.