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Metabolite Production

Once metabolites have been identified through radio-labeling or metabolism studies, we can set you up to screen and optimize and produce metabolites directly from drug candidates through a service offered by our friends at HepatoChem. HepatoChem’s BMO (BioMimetic Oxidation) and O-Glucuronidation services are utilized for rapid metabolite synthesis for phase I or II metabolism.

Metabolite production with our partners at HepatoChem

Phase I Metabolism

Using an optimized panel of catalytic chemical reaction conditions using organometallic catalysts in a multi-well parallel format, the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes can be mimicked, offering a unique synthetic chemical liver. This chemical liver offers the advantage of scalability of chemistry.

When a reaction condition is identified, it is optimized and scaled up to produce mg quantities of metabolites for both MS/MS and NMR.

Phase II Metabolism

Glucuronide formation can be a major avenue of drug metabolism.

O-Glucuronidation enhances the bile/plasma ratio of a metabolite relative to the parent drug. However, glucuronides are more polar and ionic than the parent drug, and while most glucuronides are inactive, they are not always lower in toxicity or inactivation. This service is intended to identify reaction conditions that produce the glucuronide adduct of a drug and produce mg quantities of O-Glucuronides quickly and inexpensively.

Benefits of the Metabolite Production Service:

  • Perfect if LC-MS or chemist time is not available at your lab
  • All work is performed by experienced Hepatochem platform users
  • No solvents, no disposal
  • Your team can remain focused on higher priority work

More about HepatoChem

For more than a decade HepatoChem has been offering metabolite production services to the pharmaceutical industry. Their unique process provides reaction capabilities with chemical catalysts that mimic oxidative metabolism and glucuronidation. Find more specifics on their website:

How drug metabolism fits in

How your compound breaks down and what it breaks down into tell a critical part of the story and safety of an investigational new drug. Learn more about the role of Drug Metabolism and Pharmacokinetics in drug development and the preclinical pieces to keep in mind as you move through the pipeline

Researcher Preparing Rat Liver Tritosomes