SLC (Uptake) Drug Transporter Assay Design
The inhibitory effect of the drug candidate is evaluated by measuring the uptake of the probe substrate in the presence of multiple test compound concentrations. These data can then be used to calculate an IC50 value (concentration causing 50% inhibition of transporter-mediated transport).
Drug Transport-Related Resources
For more information to guide your decision making on timing and individual transporters to assess, access our Drug Transporters Decision Tree, a poster comparing of regulatory expectations between FDA, EMA, and PMDA or our collection of transporter-related scientific content. Additional features of our drug transport study design and a chart of known clinically relevant transporter DDIs can be found on our Drug Transport Services page.