Cryoplateable Human Hepatocytes

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Cryoplateable hepatocytes are the closest alternative to using fresh hepatocytes and are unique in their ability to attach to collagen substratum and respond to prototypical inducers even after being cryogenically frozen.

Cryopreservation allows for long-term testing from the same donor while maintaining the ability to respond to prototypical inducers, maintain drug metabolizing enzymes and express transporter activity. Since these cryopreserved hepatocytes are not as time-sensitive as fresh hepatocytes, they are most commonly used for long-term metabolic stability, induction and toxicity, and transporter studies.

 

Characterization Provided

 
Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Diclofenac 4'-hydroxylation
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP3A4/5 Testosterone 6β-hydroxylation
CYP3A4/5 Midazolam 1'-hydroxylation
UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
*Fold Induction for CYP1A2, 2B6 and 3A4 determined by measuring mRNA levels and enzymatic activities.



Features and Benefits

  • Large lot sizes
  • Convenient and ready to use
  • Market-leading characterization data available online
  • High viability and cell yield

View Sekisui XenoTech's cryopreserved hepatocyte thawing and plating protocol here.

View Sekisui XenoTech's cryoplateable animal hepatocyte lots. Buy cell and tissue based products
Product Description Volume AMY
H1000.H15B+ Inducing cryopreserved male human hepatocytes, AMY 4 mil. 1mL 4 million
H1000.H15C+ Inducing cryopreserved male human hepatocytes, AMY 6 mil. 1mL 6 million
H1500.H15B+ Inducing cryopreserved female human hepatocytes, AMY 4 mil. 1mL 4 million
H1500.H15C+ Inducing cryopreserved female human hepatocytes, AMY 6 mil. 1mL 6 million
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