CryostaX® Pooled Human Hepatocytes

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CryostaX® is Sekisui XenoTech’s patented (Patent 9,642,355), single freeze pooled human hepatocyte product and is the largest multi-donor pool available using a single-freeze process. CryostaX® is designed to provide long-term consistent results, extensive characterization, the highest possible enzymatic activity and on-demand custom-pooling at no additional charge and no minimum orders.

CryostaX® features 10 and 20-donor pools, plus custom on-demand options based on individual enzyme activities and/or donor demographics from over 200 potential donors. Whatever your study requires, XenoTech can meet your needs with the widest variety of pooled human hepatocytes commercially available.

An example of no-charge custom pooling of CryostaX is shown below. By characterizing each individual donor, Sekisui XenoTech enables you to pick from an extensive list of available tissue and design your own pools. By using the characterization data it is possible to determine a quick snapshot of the designed pool's overall activities.


 

Characterization Provided

 
Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Diclofenac 4'-hydroxylation
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP3A4/5 Testosterone 6β-hydroxylation
CYP3A4/5 Midazolam 1'-hydroxylation
UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
OCT1 1-Methyl-4-phenylpyridinium iodine
OATP1B1 Estrone-3-sulfate
OATP1B3 Cholecystokinin-8
NTCP Taurocholic acid


Features and Benefits


View Sekisui XenoTech's cryopreserved hepatocyte thawing protocol here. Buy cell and tissue based products
Product Description Volume AMY
HPCH10 CryostaX, Single Freeze pooled cryopreserved human hepatocytes, 10 donor, AMY 5 million Each 5 million
HPCH20-50 CryostaX, Single Freeze pooled cryopreserved human hepatocytes, 20 donor, AMY 5 million Each 5 million
Or Create a Custom Pool
What criteria would you like to use to create your custom pool?
Use*:
Specific Enzyme Activity
Assured Minimum Yield (AMY)
Pool Size
BMI
Disease State
Age, Ethnicity &/or Gender
Alcohol, Tobacco &/or Drug Use
Serologies
Name / Company*:
Email / Phone*:
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