HepatoSure® Pooled Human Hepatocytes

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HepatoSure® is Sekisui XenoTech’s 100-donor pool of cryopreserved human hepatocytes. The largest pool on the market, HepatoSure® provides the best value when it comes to consistency of data reproducibility. Each order of HepatoSure® is shipped with the HepatoSure® Optimization Kit, a nutrient rich media which ensures consistent cell yield and the highest possible viability.

Sekisui XenoTech offers two different cryopreserved pooled human hepatocyte products, HepatoSure® and CryostaX®, and has the widest variety of human hepatocyte products on the market. 
 

Characterization Provided

 
Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Diclofenac 4'-hydroxylation
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP3A4/5 Testosterone 6β-hydroxylation
CYP3A4/5 Midazolam 1' -hydroxylation
UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
AO p-Vanillin
AO Phthalazine
OCT1 1-Methyl-4-phenylpyridinium iodine
OATP1B1 Esterone sulfate
OATP1B3 Cholecystokinin-8
NTCP Taurocholic acid
*Includes intrinsic clearance for CYP1A2, 2C8, 2C9, 2D6 and 3A4/5


Features and Benefits of HepatoSure®

  • 100 donors reducing inter-individual variability
  • Large donor pool size reduces lot-to-lot variability
  • Large lot sizes
  • Most extensive characterization on the market; includes transporter activities, AO activity and intrinsic clearance values
  • High viability and enzyme activity levels
  • Maintains strong viability for up to 4 hours

View XenoTech's cryopreserved hepatocyte thawing protocol here.
  Buy cell and tissue based products
Product Description Volume AMY
HCP100.H15 HepatoSure pooled cryopreserved human hepatocytes, 100 donors, AMY 5 million 1mL 5 million
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