Single-Donor Human Hepatocytes

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Single-donor cryopreserved human hepatocytes for suspension are a preferred test system for phase I and II in vitro drug metabolism studies. Sekisui XenoTech’s human hepatocytes for suspension come in three different assured minimum yield (AMY) categories, allowing us to customize your order to meet the specific needs of your study.

Similar to our cryoplateable human hepatocytes, donors can be selected based on enzyme activity, demographics and any other characteristics. Uptake transporter characterization is also available for select lots.

If your study requires hepatocytes not included in our standard product offering, contact one of our product specialists to find out how Sekisui XenoTech’s Custom Products can meet your needs.
 

Characterization Provided

 
Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Diclofenac 4'-hydroxylation
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP3A4/5 Testosterone 6β-hydroxylation
CYP3A4/5 Midazolam 1'-hydroxylation
 UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
OCT1* 1-Methyl-4-phenylpyridinium iodine
OATP1B1* Estrone-3-sulfate
OATP1B3* Cholecystokinin-8
NTCP* Taurocholic acid

*Uptake transporter characterization available on specified lots


Features and Benefits

  • Fully characterized using validated LC/MS/MS methods
  • Various AMY categories for easier product selection
  • Individual donor selection

View Sekisui XenoTech's cryopreserved hepatocyte thawing protocol here.
  Buy cell and tissue based products
Product Description Volume AMY
H1000.H15-3 Cryopreserved male human hepatocytes, AMY 3 mil. 1mL 3 million
H1000.H15B Cryopreserved male human hepatocytes, AMY 4 mil. 1mL 4 million
H1000.H15C Cryopreserved male human hepatocytes, AMY 6 mil. 1mL 6 million
H1000.H15T Transporter qualified cryopreserved male human hepatocytes, AMY 4 mil. 1mL 4 million
H1500.H15-3 Cryopreserved female human hepatocytes, AMY 3 mil. 1mL 3 million
H1500.H15B Cryopreserved female human hepatocytes, AMY 4 mil. 1mL 4 million
H1500.H15C Cryopreserved female human hepatocytes, AMY 6 mil. 1mL 6 million
H1500.H15T Transporter qualified cryopreserved female human hepatocytes, AMY 4 mil. 1mL 4 million
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