Transporter Certified Hepatocytes

Current Promotions

Select lots of Sekisui XenoTech cryoplateable human hepatocytes have been certified by a 3rd party* to culture for 5 days and maintain both uptake and efflux transporters as well as proper bile canaliculi formation. The transporter-certified hepatocytes have passed a multi-point evaluation starting with plating/culturing characteristics and ending with a broad evaluation of hepatic functions including uptake and efflux transporter functions, metabolic function and baseline bile acid synthesis/production. Each lot of certified hepatocytes contains the following information:

Transporter Activity

Probe Substrate Hepatic Transporter
Rosuvastatin Uptake (OATPs)
Pravastatin Uptake (OATPs)
Taurocholate Uptake (NTCP, OATPs)
Methotrexate Uptake (OAT1, OAT3)
Metformin Uptake (OCT1)
Taurocholate Efflux (BSEP)
Digoxin Efflux (P-gp)
Metformin Efflux (MATE 1)
Rosuvastatin Efflux (MRP2 / BCRP)
Pravastatin Efflux (BCRP / MRP2)
Methotrexate Efflux (BCRP / MRP2)
Includes Transported Relative to Fresh Hepatocytes

Bile Acid Profiles 

% Glycine conjugates and % Taurine conjugates for the following:
  • Transporter Certified™ lot
  • Fresh hepatocytes
  • In vivo

Hepatic Exposure (Kp Ratio) Provided

Kp ratios for Transporter Certified and fresh hepatocytes using the following substrates:
  • Taurocholate
  • Digoxin
  • Metformin
  • Rosuvastatin
  • Pravastatin
  • Methotrexate


Additional Information Provided

  • Viability
  • Cell yield
  • Protein content (mg/mL in 24-well)
  • Conjugation capacity and biliary excretion
  • Drug-transporter interactions
Buy cell and tissue based products
Product Description Volume
H1000.H15Q Cryoplateable Male Human Hepatocytes, Qualyst Transporter Certified 1mL
H1500.H15Q Cryoplateable Female Human Hepatocytes, Qualyst Transporter Certified 1mL
Find the Cellular Products You Need  
Can't find what you need? Have a question?
(please note: pressing Enter will submit the form)
Or Call 1-877-588-7530
(+1.913.438.7450 If Outside North America)

*Operated under a license from Qualyst Transporter Solutions, which provided the Transporter Certification™ and owns B-CLEAR®.
Contact Us

Contact Us

Questions or inquiries? Use our contact form and we’ll reply as soon as possible.* indicates required field

Request A Quote
Request A Quote

Request A Quote

 Security code