Lysosomes and Tritosomes

Lysosomes are membrane-bound cellular organelles that are the site of degradation / catabolism, including extracellular substrates (endocytic pathway) and intracellular substrates (autophagy pathway). Lysosomes contain a multitude of acidic hydrolytic enzymes, vary greatly in size and have Isopycnic densities similar to mitochondria. Considering their unique pH and the presence of a variety of catabolic enzymes, therapeutic strategies are being designed to take advantage of lysosomes as the primary site of catabolism/activation for targeted biopharmaceuticals that enter cells through the endosomal-lysosomal pathway.

Tritosomes are lysosomes isolated from Tyloxapol-treated animals for improved separation of the organelle from the mitochondria. Our rat liver tritosomes compliment human hepatic lysosomes as an in vitro reagent with a rat matrix. Learn more about tritosomes on our rat liver tritosomes and tritosome FAQ pages.
Lysosomes/tritosomes can be used as an in vitro diagnostic tool to conveniently, cost-effectively and quickly evaluate potential changes in lysosomal stability due to targeted modifications of the biopharmaceutical / macromolecule during development. The data can help narrow and direct development tracks of biopharmaceuticals such as those interested in ADCs, siRNA/RNAi technologies, immunotherapies, biodegradable copolymers and nanoparticles as delivery mechanisms; cosmetics using microparticles; etc.

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