Lysosomes and Tritosomes

Lysosomes are membrane-bound cellular organelles that are the site of degradation / catabolism, including extracellular substrates (endocytic pathway) and intracellular substrates (autophagy pathway). Lysosomes contain a multitude of acidic hydrolytic enzymes, vary greatly in size and have Isopycnic densities similar to mitochondria. Considering their unique pH and the presence of a variety of catabolic enzymes, therapeutic strategies are being designed to take advantage of lysosomes as the primary site of catabolism/activation for targeted biopharmaceuticals that enter cells through the endosomal-lysosomal pathway.


Tritosomes are lysosomes isolated from Tyloxapol-treated animals for improved separation of the organelle from the mitochondria. Our rat liver tritosomes compliment human hepatic lysosomes as an in vitro reagent with a rat matrix. Learn more about tritosomes on our rat liver tritosomes and tritosome FAQ pages.
Lysosomes_OptiPrep-Gradient.jpg
Lysosomes/tritosomes can be used as an in vitro diagnostic tool to conveniently, cost-effectively and quickly evaluate potential changes in lysosomal stability due to targeted modifications of the biopharmaceutical / macromolecule during development. The data can help narrow and direct development tracks of biopharmaceuticals such as those interested in ADCs, siRNA/RNAi technologies, immunotherapies, biodegradable copolymers and nanoparticles as delivery mechanisms; cosmetics using microparticles; etc.

Buy cell and tissue based products

Available Lysosome and Tritosome Products:

  Find the Cellular Products You Need  
Can't find what you need? Have a question?
Or Call 1-877-588-7530
(+1.913.438.7450 If Outside North America)

 
Contact Us

Contact Us

Questions or inquiries? Use our contact form and we’ll reply as soon as possible.* indicates required field

Request A Quote
Request A Quote

Request A Quote

 Security code