Human Intestine Subcellular Fractions

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Using intestinal subcellular fractions as a test system is highly recommended due to the importance of intestinal enzymes in the first-pass metabolism of many orally ingested xenobiotics. Consequences of intestinal biotransformation can be very significant, including toxification by bioactiviation and detoxification by aiding in excretion.

Sekisui XenoTech only extracts intestinal subcellular fractions from mature enterocytes of the villus tips, ensuring the highest possible CYP and UGT enzyme activity levels. As such, Sekisui XenoTech’s human intestinal microsomes and S9 have the highest activity levels on the market.

For high esterase activity, choose Sekisui XenoTech's PMSF-free intestine subcellular fractions.
PMSF* is a serine protease inhibitor that inactivates trypsin and chymotrypsin found within the small intestine, but can also inhibit esterase activity in intestine subcellular fractions and interfere with your esterase assays. Our proven preparation method is essentially the same, without the addition of PMSF. Learn more here.

*PMSF (Phenylmethylsulfonylflouride)

Features and Benefits:
  • Large donor pools minimize lot-to-lot variation
  • Highest activity levels commercially available
  • Extremely stable over multiple freeze/thaw cycles
  • Matching microsomes and S9 donor pools
  • Extensively characterized
 
If you require subcellular fractions not included in our standard product offering, custom products can be conveniently ordered to meet the needs of any study.

For more information on extrahepatic products, download our subcellular fraction flyer or contact a XenoTech Product Specialist today.
 
Related Products:
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Product Description Volume Protein Concentration
H0610.I Pooled human intestinal microsomes, mixed gender, 10mg/mL 0.15mL 10 mg/mL
H0610.IC Mixed gender human intestinal cytosol 1mL 4 mg/mL
H0610.IS9 Pooled human intestinal S9 fraction, mixed gender, 4mg/mL 1mL 4 mg/mL
H0610.I(NP) Pooled human intestinal microsomes, PMSF free, mixed gender, 10mg/mL 0.15mL 10 mg/mL
H0610.IC(NP) Pooled Human intestinal cytosol, PMSF free, mixed gender, 1.0 mL at 4mg/mL 1mL 4 mg/mL
H0610.IS9(NP) Pooled human intestinal S9 fraction, PMSF Free, mixed gender, 4mg/mL 1mL 4 mg/mL
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