CYP2C19 Genotyped Microsomes

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XenoTech's genetically-defined products include human liver microsomes prepared from individual donors characterized for various CYP2C19 alleles corresponding to high activity, moderate activity and no activity.

Enzymatic activities of CYP2C19 vary significantly among ethnic populations, making it highly important for pharmaceutical studies. CYP2C19 is known to metabolize omeprazole, lansoprozole, propranolol, imipramine, mephenytoin, chloroguanide, hexabarbitone and diazepam. CYP2C19 polymorphisms that result in low CYP2C19 activity increase the risk of adverse reactions to some drugs. 
The most common variants are CYP2C19*2 (681 G>A) and CYP2C19*3 (636G>A) (Scordo et al. 2004). CYP2C19*2 has a frequency as low as 0.091 in Caucasians and as high as 0.40 in some Asian populations; CYP2C19*3 is common only in Asian populations. CYP2C19*2 or CYP2C19*3 contribute to the majority of poor-metabolizer phenotypes in Caucasians and Asians but CYP2C19*4 and CYP2C19*5 also lack enzymatic activity. Phenotypically, poor metabolizers occur in 13 – 23% of Asian populations and 2 – 5% of Caucasian populations.

CYP2C19 Allele Frequency
Allele African
Asian Caucasian Hispanic
CYP2C19*1 0.75 - 0.87 0.540 - 0.70 0.83 - 0.909 N/A
CYP2C19*2 0.10 - 0.25 0.20 - 0.40 0.091 - 0.161 N/A
CYP2C19*3 0.0 - 0.02 0.0 - 0.14 0.0 - 0.04 N/A
CYP2C19*4 ND 0.0 - 0.05 0.0 - 0.011 N/A
CYP2C19*5 ND 0.0 - 0.0025 ND N/A
N/A = No data available
ND = Not detected
Adapted from Xiao, et. al, 1997, Hamdy, et. al, 2002, Allabi, et. al, 2003, Melis, et. al, 2006, Tassaneeyakul, et. al, 2006, Rosemary and Adithan, 2007 and Zandvliet, et. al, 2007.
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Product Description Volume
H2C19.HA Individual Human Liver Microsomes - Genotyped for CYP2C19 - High Activity - 20mg/mL 0.5mL
H2C19.MA Individual Human Liver Microsomes - Genotyped for CYP2C19 - Moderate Activity - 20mg/mL 0.5mL
H2C19.NA Individual Human Liver Microsomes - Genotyped for CYP2C19 - No Activity - 20mg/mL 0.5mL
*All genotyped human liver microsomes are supplied at a protein concentration of 20 mg/mL in 250 mM sucrose
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