CYP2D6 Genotyped Microsomes

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XenoTech's collection of genetically-defined human liver microsomes represents all major genotypes of CYP2D6. On the high end of the CYP2D6 activity spectrum, we offer microsomes from donors carrying duplication of fully active alleles, referred to as ultra rapid metabolizers. On the low end of the CYP2D6 activity spectrum, we provide microsomes from donors carrying two inactive alleles.
 
CYP2D6 expressed more alleles than any other drug-metabolizing human P450 enzyme. Genetic polymorphism is the most common cause of the interindividual differences in metabolism of CYP2D6 substrates. Detailed descriptions of the nucleotide changes characterizing individual alleles and their effects on the CYP2D6 phenotype can be found at www.cypalleles.ki.se.
 
Genotypes present in our collection are organized based on activity score as defined by Gaedigk, et. al, 2008. This is a numerical expression based on the presence of fully-, partially-functional and non-functional alleles, shown here in Table 1.

Table 1: CYP2D6 Activity Score and the corresponding donor genotypes in the XenoTech collection of individual human liver microsomes
 
Activity
Score
Genotype Activity
3 *1/*2x2 High Activity
2.5 *2x2/*41 Moderate Activity
2 *1/*1, *1/*2, *2/*2 Moderate Activity
1.5 *1/*9, *1/*29, *1/*41, *2/*41 Moderate Activity
1 *1/*3, *1/*4, *1/*5, *2/*3, *2/*4, *17/*29, *41/*41 Moderate Activity
0.5 *4/*9, *4/*41, *5/*41, *6/*9 Moderate Activity
0 *4/*4, *4/*5, *4/*6 No Activity

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Product Description Volume
H2D6.HA Individual human liver microsomes, Genotyped for CYP2D6, high activity, 20mg/mL 0.5mL
H2D6.MA Individual human liver microsomes, Genotyped for CYP2D6, moderate activity, 20mg/mL 0.5mL
H2D6.NA Individual human liver microsomes, Genotyped for CYP2D6, no activity, 20mg/mL 0.5mL
*All genotyped human liver microsomes are supplied at a protein concentration of 20 mg/mL in 250 mM sucrose
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