CYP3A5 Genotyped Microsomes

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XenoTech's genetically-defined products include human liver microsomes prepared from individual donors characterized for three CYP3A5 allelic categories, high activity (*1/*1), moderate activity (*1/*3) and no activity (*3/*3). Microsomes are available from each CYP3A5 genotype category.
 
Members of the CYP3A family are the most abundant CYP enzymes in the human liver and intestine, influencing circulating steroid levels and responsible for the oxidative metabolism of half of all drugs. When it is present, CYP3A5 can represent up to 50% of the total CYP3A protein in liver microsomes, suggesting an important role in the clearance of CYP3A substrates.
 
There are substantial CYP3A expression differences between individuals, which contributes greatly to variation in oral bioavailability and systemic clearance of CYP3A substrates. There are also pronounced inter-racial differences in CYP3A5 allelic frequency. The table below demonstrates allelic frequency variations among different races.

CYP3A5 Allele Frequency
 
Allele African
American
Asian Caucasian Hispanic
CYP3A5*1 0.45 - 0.73 0.15 - 0.38 0.05 - 0.15 0.25
CYP3A5*3 0.06 - 0.50 0.60 - 0.76 0.82 - 0.96 0.46 - 0.71
Adapted from Thompson, et al. 2004, Wang, et al. 2006, Kuehl, et al. 2001 and Lamba, et al. 2002.
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Product Description Volume
H3A5.HA Individual human liver microsomes, Genotyped for CYP3A5, high activity, 20mg/mL 0.5mL
H3A5.MA Individual human liver microsomes, Genotyped for CYP3A5, moderate activity, 20mg/mL 0.5mL
H3A5.NA Individual human liver microsomes, Genotyped for CYP3A5, no activity, 20mg/mL 0.5mL
*All genotyped human liver microsomes are supplied at a protein concentration of 20 mg/mL in 250 mM sucrose
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