Human Liver Microsomes

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Human liver microsomes contain a wide variety of drug metabolizing enzymes and are commonly used to support in vitro ADME (Absorption, Distribution, Metabolism and Excretion) studies. These microsomes are used to examine the potential for first-pass metabolism of orally administered drugs.

Sekisui XenoTech features pooled products which are engineered for specific higher CYP activities or a large donor pool that better represents the average American population. Individual donors that comprise these products are each significantly represented in the final pools we prepare. Sekisui XenoTech offers the 200-donor XTreme pool as well as our 10- and 50-donor pooled human liver microsome products. XTreme 200 is the largest commercially-available pool of human liver microsomes.

Additionally, Sekisui XenoTech offers a patented Reaction Phenotyping Kit designed to identify the human liver CYP or UGT enzyme(s) responsible for xenobiotic metabolism. This kit is often used to predict pharmacokinetic variability and provides valuable information on the potential for drug-drug interactions.

Click here to view the reaction phenotyping usage guide.

Features and Benefits:
  • Large donor pools minimize lot-to-lot variation and increase the long-term availability of each lot
  • Suspended in 250mM sucrose for long-term stability
  • Sold in several different volume sizes and custom packaging is available upon request
  • Extensively characterized for 10 CYPs, FMO and 5 UGTs
  • CYP activities determined using validated LC-MS/MS methods
  • Matching S9 and Cytosol available for most donor pools
 
Custom human liver microsome products can be prepared if your study has specific donor requirements.
 
Related Products:  
For more information, download our subcellular fraction flyer or contact a XenoTech Product Specialist today.

View available lots and characterization information here. Buy cell and tissue based products
Product Description Pool Size Volume
H0500 Reaction Phenotyping Kit, Human liver microsomes Each
H0604 CMV-, pooled human liver microsomes, mixed gender, 0.5mL, 20mg/mL 8 0.5mL
H0610 Pooled human liver microsomes, mixed gender, 0.5mL, 20mg/mL 50 0.5mL
H0610-81 Pooled human liver microsomes, mixed gender, 81 vial kit, 20mg/mL 50 Each
H0620 Pooled human liver microsomes, mixed gender, 1mL, 20mg/mL 50 1mL
H0630 Pooled human liver microsomes, mixed gender, 5mL, 20mg/mL 50 5mL
H0640 Pooled human liver microsomes, mixed gender, 50mL, 20mg/mL 50 50mL
H1000 Pooled human liver microsomes, male, 0.5mL, 20mg/mL 10 0.5mL
H1500 Pooled human liver microsomes, female, 0.5mL, 20mg/mL 10 0.5mL
H2610 XTreme 200 pool human liver microsomes, mixed gender, 0.5mL, 20 mg/mL 200 0.5mL
H2610-81 XTreme 200 pooled human liver microsomes, mixed gender, 81-count box, 20mg/mL 200 Each
H2620 XTreme 200 pool human liver microsomes, mixed gender, 1mL, 20 mg/mL 200 1mL
H2630 XTreme 200 pool human liver microsomes, mixed gender, 5mL, 20 mg/mL 200 5mL
H2640 XTreme 200 pool human liver microsomes, mixed gender, 50mL, 20 mg/mL 200 50mL
*All human liver microsomes are supplied at a protein concentration of 20 mg/mL in
250 mM sucrose

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Human Liver Microsomes Research
Poster: UGT Inhibition Studies in the Presence or Absence of Alamethicin
Poster: Evaluation of Chemical Inhibitors for UDP-glucuronosyltransferase (UGT) Reaction Phenotyping Assays in Human Liver Microsomes
Poster: Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in Pooled Human Liver Microsomes and Hepatocytes
Poster: The Effect of Buffer Ionic Strength or Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates in Pooled Human Liver Microsomes and Cryopreserved Human Hepatocytes
Paper: In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal
Poster: Test system-dependent clearance of CYP2D6 and CYP3A4/5 substrates
Poster: Midazolam clearance in human hepatocytes is restricted compared with human liver microsomes but not by cell permeability or cofactor availability
Poster: In vitro inhibition and induction of human liver cytochrome P450 enzymes by NTBC and its metabolism in human liver microsomes

View more research...
 
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