Human Liver S9

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Sekisui XenoTech's S9 fraction is a mixture of microsomes and cytosol. S9 fractions contain a wide variety of drug metabolizing enzymes and are commonly used to support in vitro ADME (Absorption, Distribution, Metabolism and Excretion) studies, including phase I and phase II xenobiotic metabolism.

Sekisui XenoTech features four different human liver S9 products with matching microsomal and cytosolic fraction donor pools.
  • XTreme 200 Pooled Human Liver S9
  • 50-Donor Mixed Gender Human Liver S9
  • 10-Donor Male Human Liver S9
  • 10-Donor Female Human Liver S9
 
New! Sekisui XenoTech also offers donor pools that have been prepared to preserve high AO (aldehyde oxidase) and XO (xanthine oxidase) activity without significantly impacting major CYP activity (view poster), usually with matching S9 and cytosol pools.

Human Liver S9 Test System Features and Benefits:
  • Matching Microsomes, S9 and Cytosol for most donor pools
  • Large donor pools minimize lot-to-lot variation and increase the long-term availability of each lot.
  • Extensively characterized using validated LC-MS/MS methods
 
Related Products:  
Custom human liver S9 can be prepared if your study has specific donor requirements. For more information on S9 fractions, download our subcellular fraction flyer or contact a XenoTech Product Specialist today.

View available lots and access characterization information below: Buy cell and tissue based products
Product Description Pool Size Volume
H0606.S9(AX) Human Liver S9 Fraction - High AO/XO Activity Mixed Gender, Pool of 20 20 1mL
H0610.S9 Pooled human liver S9 fraction, mixed gender, 0.5mL, 20mg/mL 50 0.5mL
H0620.S9 Pooled human liver S9 fraction, mixed gender, 1mL, 20mg/mL 50 1mL
H0630.S9 Pooled human liver S9 fraction, mixed gender, 5mL, 20mg/mL 50 5mL
H0640.S9 Pooled human liver S9 fraction, mixed gender, 50mL, 20mg/mL 50 50mL
H1000.S9 Pooled human liver S9, male fraction, 1.0mL, 20 mg/mL 10 1mL
H1500.S9 Pooled human liver S9 fraction, female, 1.0 mL, 20mg/mL 10 1mL
H2610.S9 XTreme pooled human liver S9 fraction, mixed gender, 0.5mL, 20 mg/mL 200 0.5mL
H2620.S9 XTreme pooled human liver S9 fraction, mixed gender, 1mL, 20 mg/mL 200 1mL
H2630.S9 XTreme pooled human liver S9 fraction, mixed gender, 5mL, 20 mg/mL 200 5mL
H2640.S9 XTreme pooled human liver S9 fraction, mixed gender, 50mL, 20 mg/mL 200 50mL
*S9 fractions are supplied at a concentration of 20 mg/mL, in 50 mM TRIS-HCI, (pH 7.4 at 4ºC) containing 150 mM KCI and 2 mM EDTA.
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Human Liver S9 Fraction Scientific Resources
Poster: The Effects of Organ Preservation Solution on Aldehyde Oxidase and Xanthine Oxidase Activity in Pooled Human Liver S9
Paper: Aldehyde Oxidase - Why In Vitro Absolute Activity Doesn't Matter
Poster: Selection of human liver S9 and cytosol fractions for evaluating clearance by aldehyde oxidase (AO)
Poster: Human liver S9 fractions stored at -70°C maintain high phase I and phase II enzymatic activities over multiple freeze/thaw cycles and for at least 10 years

View more research...
 
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