Efficient use of chimeric mice with humanized livers for drug development support

Efficient use of chimeric mice with humanized livers for drug development support

Published:  11/14/2015 1:10:07 PM

Chimeric mice with humanized livers can be used to obtain supportive data for selecting the best candidate compound for new drug development. To utilize this costly animal model efficiently, we tried to verify that consecutive experiments could be conducted with the same animals to generate predictive human ADME.

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