Patterns of Hyaluronan Deposition in Normal and Diseased Pediatric Livers

Patterns of Hyaluronan Deposition in Normal and Diseased Pediatric Livers

Published:  3/13/2019 8:45:25 AM

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD
Maciej CzerwiƄski1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele T. Pritchard3,5
1
Sekisui XenoTech, Kansas City, KS., 2Department of Pathology and Laboratory Medicine, Children’s Mercy Hospital, Kansas City, MO., 3Department of Pharmacology, Toxicology and Therapeutics, 4Kansas Intellectual and Developmental Disabilities Research Center, 5The Liver Center, University of Kansas Medical Center, Kansas City, KS

The incidence of obesity and non-alcoholic fatty liver disease (NAFLD) is growing in children. Hyaluronan (HA), an extracellular matrix (ECM) glycosaminoglycan, is increased in liver and blood from adults with advanced liver disease. HA accumulation is also associated with inflammation and fibrosis in extrahepatic tissues. HA levels have not been examined in healthy or diseased livers from pediatric patients. Here, we sought to determine if hepatic HA deposition was associated with donor age and/or disease by using a pediatric liver tissue microarray (TMA)...

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