Drug Metabolizing Enzymes and Transporters in NASH

Drug Metabolizing Enzymes and Transporters in NASH

Aired:  2/15/2017 8:00:00 AM

Research Application of Variants of Fatty Liver Disease (FLD) Tissues

Presented by Maciej Czerwinski, Ph.D., Sekisui XenoTech Director of Consulting

Sekisui XenoTech is committed to the support of research into human diseases, particularly of the liver. In the course of over twenty years of pharmacokinetic studies in human hepatocytes, we have accumulated normal and diseased tissues representing FLD with or without history of excessive alcohol consumption and steatohepatitis. In this webinar, characteristics of the FLD and the effects of the condition on drug metabolism and disposition will be outlined. Organ collection procedures, storage and characterization of the specimens, as well as features of donors with and without significant consumption of alcohol, T2 and T1DM and pediatric donors will be described.

Key concepts discussed:
  • Fatty liver disease – characterization and progression
  • Effects of fatty liver diseases on drug metabolism and transport

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