Metabolite Production

Once metabolites have been identified through radio-labeling or metabolism studies, Sekisui XenoTech can screen, optimize and produce metabolites directly from drug candidates. Using HepatoChem’s BMO Kits (BioMimetic Oxidation Kits) and O-Glucuronidation Kits, we provide rapid metabolite synthesis for phase I or II metabolism.
Phase I Metabolism
Utilizing an optimized panel of catalytic chemical reaction conditions using organometallic catalysts in a multi-well parallel format, Sekisui XenoTech can mimic the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes, offering a unique synthetic chemical liver. This chemical liver offers the advantage of scalability of chemistry. When a reaction condition is identified, it is optimized and scaled up to produce mg quantities of metabolites for both MS/MS and NMR.
Phase II Metabolism
Glucuronide formation can be a major avenue of drug metabolism. O-Glucuronidation enhances the bile/plasma ratio of a metabolite relative to the parent drug. However, glucuronides are more polar and ionic than the parent drug, and while most glucuronides are inactive, they are not always lower in toxicity or inactivation. Sekisui XenoTech can identify reaction conditions that produce the glucuronide adduct of a drug, producing mg quantities of O-Glucuronides quickly and inexpensively.

Benefits of the Metabolite Production Service:
  • Perfect if LC-MS or chemist time is not available at your lab
  • All work is performed by experienced Hepatochem platform users
  • No solvents, no disposal
  • Your team can remain focused on higher priority work
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