In Vitro UGT Induction (Definitive)

Overview

Sekisui XenoTech UGT in vitro enzyme induction studies can be designed to meet the needs of the client and compound in question to compliment UGT drug metabolism results. The study design will be similar to Sekisui XenoTech's in vitro CYP induction study options. Definitive UGT induction studies utilize fresh or cryopreserved primary human hepatocytes.

We recommend the following study design for in vitro UGT induction studies:
  • Fresh primary human hepatocytes
  • UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B4 and UGT2B7 mRNA expression by qRT-PCR
  • Multiple concentrations of test article (how to choose your concentration range)
  • Vehicle control (test article solvent)
  • Multiple positive controls (prototypical CYP inducers)
  • Pre-study solubility testing
  • Full submission quality report
  • Non-GLP

Optional extras:
  • UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7 and UGT2B17 microsomal based activity by single substrate incubation
  • Pre-induction study toxicity assessment
  • Full GLP Dose Solution Analysis on-site
  • Spent media analysis with multiple time point collections
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<< Enzyme Induction
In vitro CYP Induction (Definitive)
In vitro Induction Express (Screening)
Ex vivo CYP and UGT Enzyme Induction
Cytotoxicity
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