Enzyme Inhibition

Sekisui XenoTech's Enzyme Inhibition Services

The clearance of a drug (victim) by a particular enzyme can be impaired if it is administered with a second drug (perpetrator) that inhibits that particular enzyme. The primary purpose of evaluating drugs as inhibitors of certain enzymes is to determine their perpetrator potential before advancing a drug candidate to late stage development. Sekisui XenoTech offers well-designed Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) in vitro studies that meet or exceed the FDA and/or EMA's latest regulatory guidance.

Our Enzyme Inhibition group offers the following services:

 

Enzyme Inhibition Automation and Analysis

  • Tecan liquid handling systems or manual incubations available
  • Validated LC-MS/MS methods
  • High throughput autosamplers
  • Deuterated internal standards (all CYPs and most UGTs)
  • Automated data retrieval and processing
  • Comprehensive, publication-quality reports
  • Available as GLP or non-GLP
  Find the Services You Need  
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(+1.913.438.7450 If Outside North America)
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