Radio-Labeled Synthesis


Early stage knowledge of the pharmacological effects of an investigational drug in the human body has become increasingly important in order to avoid costly late-stage clinical trial failures. For this reason, industry is more frequently conducting ADME studies in humans to better evaluate the performance of a drug early in the development cycle (usually in Phase I).

In order to study a drug's disposition, it is common to place a radioactive tag at a metabolically stable site on the investigational drug. Using the radioactive tag, we are able to identify any metabolites and detect structurally unidentified metabolites. Performing radiolabeled synthesis at an early stage, allows drug developers to make informed decisions about committing resources to the development of a chemical entity for commercial application, thereby reducing financial risk.

Sekisui XenoTech's global research team has over 50 years of experience synthesizing radiolabeled compounds and offers the following radiolabeled synthesis services:
  • 14C and 3H-labeled compound synthesis
  • 14C-fermentation
  • 3H, 33S, 35S, 90Y, 125I and 111In protein and peptide labeling
  • Re-purification and stability test
  • Storage / re-analysis
  • Synthesis of biologically active substances
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