RadioReceptor Assay (RRA)

Overview

Sekisui XenoTech's RadioReceptor Binding Assays (RRA) are excellent tools to study receptor-ligand interactions. The radioreceptor assay is a competitive binding assay in which the binder is a membrane or tissue receptor. This assay measures the inhibition ratio of the hot ligand binding to the receptor to determine the pharmacological parameter. The purpose of these studies is to evaluate the affinity of a test compound to various receptors.

Radioreceptor Assay Purpose:

  • To clarify the affinity to each receptor using radioreceptor assays and to predict the effect to each receptor.
  • If a high affinity to a certain receptor is found, we can carry out the evaluation of affinity (IC50 and/or Ki) with comparison to known drugs and further investigation with subtypes of certain receptors.
 

Assay Procedure

The positive substances, tracers and receptors must be prepared and loaded into a cell harvester (Brandel M-30R or Perkin-Elmer Unifilter-96 Harvester). The samples are then washed, measured and the radioactivity is analyzed on a Perkin-Elmer liquid scintillation counter or gamma counter.
 

Study Options

Sekisui XenoTech offers over 230 different receptor assays for RRA. We also have convenient screening packages of 20, 60 and 90 predetermined receptors for testing. Please find a list of our available receptors and a link to our online quotation portal to the right.
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