Navigating the Transporter Wave of 2013: A Review of the Seven Recent ITC Publications on Drug Transporters
Presented by: Greg Loewen, Amanda Hays and Andrea Wolff
Seven papers were published by the International Transporter Consortium (ITC) in the July 2013 issue of Clinical Pharmacology and Therapeutics. The ITC is a group of preeminent scientists from industry, academia and regulatory agencies and these seven papers represent the most current information on the study of transporters to predict possible drug-drug interactions. XenoTech will present critical highlights from each of the papers, contrast to current thinking and comment on the effect these papers will have on the drug development process.
Key concepts discussed in the webinar include:
- Emerging clinically relevant transporters
- Clinically relevant transporter polymorphisms
- Kinetic parameter estimation and translational modeling
- Potential for drug-drug interactions and the blood brain barrier
- In vitro methods for studying drug transporters
- Decision trees – in vitro results that drive in vivo studies
- Measurement, modeling and implications of intracellular drug concentrations
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