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Disease-Specific Resources

Liver disease affects millions of adults in the United States and worldwide, and is a growing risk for children as well. Pediatric liver disease affects hundreds of thousands of families around the world; the rate of occurrence has more than doubled in the last 20 years, affecting nearly 11% of adolescents. Adult and pediatric cases of liver disease can lead to cirrhosis, liver failure, and is a risk factor for liver cancer. The need to explore therapeutic avenues towards NAFLD, NASH, steatosis, and other states of liver disease and dysfunction is on the rise, necessitating research specific to pediatric liver function and drug response.

 

Webinars

Hyaluronan (HA) Synthesis Inhibition Normalizes Hepatic Fibrogenic Features by Reducing Hepatic Stellate Cell Activation in Alcohol-Associated Liver Disease Models

Presenters: Michele Pritchard, Ph.D., Associate Professor, University of Kansas Medical Center and Maciej Czerwinski, Ph.D., Director of Consulting, SEKISUI XenoTech In 2018, Dr. Pritchard published...
Webinars

ADME 101: Biobank Fatty Liver Disease Tissues and Their Exploration in Microarrays

Presenter: Maciej Czerwinski, Ph.D., SEKISUI XenoTech Director of Consulting This ADME 101 discusses biobank tissue and its research applications. The Research Biobank was established to...
Blog

New TMPRSS2-Expressing Cell Line for COVID-19 Research

We are offering a brand new cell line to assist researchers in the fight against COVID-19.The cell line (JCRB1819), developed...

Blog

What is ADME and how does it fit into drug development?

The main aim of drug development is to get a compound that has a therapeutic effect into the form of...

Scientific Posters

CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...
Scientific Posters

CYP1A2 enzyme localization in normal and diseased pediatric livers

Presented at the 55th Congress of European Societies of Toxicology (EUROTOX 2019) in Helsinki, Finland Full Poster Title “CYP1A2 Enzyme Activity and Protein Abundance In Normal...
Blog

New Liver Tissue Microarrays Available – What Would Benefit Your Research?

As technology evolves to better meet needs in exploration of drug metabolism pathways and disease mechanisms, familiarization with appropriate and...

Scientific Posters

Patterns of hyaluronan deposition in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...
Blog

Disease-State Test Systems

SEKISUI XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years...

Scientific Posters

Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis

Presented at the 2019 AASLD Liver Meeting in San Francisco, CA Authors Dr. Maciej Czerwinski1, Jordan Surgnier2, Dr. Sarah E. Tague3 and Dr. Michele T....
Scientific Posters

Microsomal cytochrome P450 (CYP) enzyme activities in nonalcoholic steatohepatitis (NASH) livers

Presented at the 22nd North American ISSX Meeting Montréal, Quebec, Canada Authors Maciej Czerwinski1, Brian Oberheide1, Nicholas Hatfield1, Bill Ewy1, Christopher Seib1, Eva Gatineau2, Frederique Yiannikouris2,...
Scientific Posters

Characteristics of Fatty Liver Disease (FLD) Tissue Infographic

Over 20+ years of pharmacokinetic studies, SEKISUI XenoTech has accumulated normal and diseased tissues representing fatty liver disease (FLD) with or without history of alcohol...
Blog

New Liver Disease Resource and Other Research Biobank News

SEKISUI XenoTech is committed to furthering the knowledge surrounding hepatic diseases, which affects one out of four people worldwide, such...

Webinars

Drug Metabolizing Enzymes and Transporters in NASH

Research Application of Variants of Fatty Liver Disease (FLD) Tissues Presented by Maciej Czerwinski, Ph.D., SEKISUI XenoTech Director of Consulting SEKISUI XenoTech is committed to the support...
Scientific Posters

Research collection of variants of normal and fatty liver disease in human livers

SEKISUI XenoTech has developed a Research Biobank that is a collection of normal, steatosis and steatohepatitis tissue samples gathered and characterized to facilitate the study...
Blog

SEKISUI XenoTech Joins Fight Against Liver Disease

SEKISUI XenoTech is committed to furthering the knowledge surrounding hepatic diseases, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic...

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