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Disease-Specific Resources

Liver disease affects millions of adults in the United States and worldwide, and is a growing risk for children as well. Pediatric liver disease affects hundreds of thousands of families around the world; the rate of occurrence has more than doubled in the last 20 years, affecting nearly 11% of adolescents. Adult and pediatric cases of liver disease can lead to cirrhosis, liver failure, and is a risk factor for liver cancer. The need to explore therapeutic avenues towards NAFLD, NASH, steatosis, and other states of liver disease and dysfunction is on the rise, necessitating research specific to pediatric liver function and drug response.

 

Webinars

Addressing Unique Challenges with Custom In Vitro Test Systems

Presenter: Zell Woodworth, Division Director of Products at XenoTech Abstract: Sometimes, standard products just don’t fit the objective of a unique assay. In this webinar, Products...
Webinars

ADME 101: Biobank Fatty Liver Disease Tissues and Their Exploration in Microarrays

Presenter: Maciej Czerwinski, Ph.D., XenoTech Director of Consulting This ADME 101 discusses biobank tissue and its research applications. The Research Biobank was established to preserve,...
Blog

New TMPRSS2-Expressing Cell Line for COVID-19 Research

We are offering a brand new cell line to assist researchers in the fight against COVID-19.The cell line (JCRB1819), developed...

Scientific Posters

CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers

Full Title CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers Authors M. Czerwinski, B. Ewy, A. Kats, M. T. Pritchard, S....
Scientific Posters

CYP1A2 enzyme localization in normal and diseased pediatric livers

Presented at the 55th Congress of European Societies of Toxicology (EUROTOX 2019) in Helsinki, Finland Full Poster Title “CYP1A2 Enzyme Activity and Protein Abundance In Normal...
Blog

New Liver Tissue Microarrays Available – What Would Benefit Your Research?

As technology evolves to better meet needs in exploration of drug metabolism pathways and disease mechanisms, familiarization with appropriate and...

Scientific Posters

Patterns of hyaluronan deposition in normal and diseased pediatric livers

Full Title Patterns of hyaluronan deposition in normal and diseased pediatric livers Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele T....
Blog

Disease-State Test Systems

XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years of...

Scientific Posters

Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis

Full Title Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis Authors Dr. Maciej Czerwinski1, Jordan Surgnier2, Dr. Sarah E. Tague3 and...
Scientific Posters

Microsomal cytochrome P450 (CYP) enzyme activities in nonalcoholic steatohepatitis (NASH) livers

Full Title Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to...
Scientific Posters

Characteristics of Fatty Liver Disease (FLD) Tissue Infographic

Full Title Characteristics of Fatty Liver Disease (FLD) Tissue Infographic Abstract Over 20+ years of pharmacokinetic studies, XenoTech has accumulated normal and diseased tissues representing...
Blog

New Liver Disease Resource and Other Research Biobank News

XenoTech is committed to furthering the knowledge surrounding hepatic diseases, which affects one out of four people worldwide, such as...

Webinars

Drug Metabolizing Enzymes and Transporters in NASH

“Drug Metabolizing Enzymes and Transporters in NASH: Research Application of Variants of Fatty Liver Disease (FLD) Tissues” Presented by Maciej Czerwinski, Ph.D., XenoTech Director of Consulting
Scientific Posters

Research collection of variants of normal and fatty liver disease in human livers

Full Title Research collection of variants of normal and fatty liver disease in human livers Abstract XenoTech has developed a Research Biobank that is a...
Blog

XenoTech Joins Fight Against Liver Disease

XenoTech is committed to furthering the knowledge surrounding hepatic diseases, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis...

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