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Small Molecule Bioanalysis Services to Support Drug Development

You can now request quotes for our research services on BioIVT.com!

Whether you need a single assay or a complete ADME program, BioIVT’s experts will help design and implement the appropriate studies for your drug and research objectives. View BioIVT’s comprehensive portfolio of ADME research services.

Our Analytical Services department offers non-regulated small molecule bioanalysis services to determine accurate measurement of parent drug and/or metabolite concentration in various biological matrices to support ADME (absorption, distribution, metabolism, and excretion), DMPK (drug metabolism and pharmacokinetics), and DDI (drug-drug interaction) studies in drug development.

Our Approach to Bioanalysis

Bioanalysis is a sub-discipline of analytical chemistry providing a quantitative measurement of a drug and/or its metabolite(s) in various biological matrices. The XenoTech Analytical Services department has over 100 years of combined experience with pharma and CROs spanning multiple disciplines including in vivo bioanalytical support. Our team of experts can provide quality, non-GLP results in 2-4 business days.

Red blood cell RBC partitioning study for drug clearance and pharmacokinetics

Our Small Molecule Bioanalytical Capabilities

  • Protein precipitation extraction (standard approach)
  • Matrices include plasma, serum, blood and urine and tissue samples
  • Development of single or multiple analyte methods to support parent and metabolite(s) analysis or cassette analysis
  • Method qualification (optional)
  • Duplicate standard curves (bracketed samples)
  • Flexible standard curve ranges up to 5000-fold (modify as needed)
  • Sample analysis by LC-MS/MS
  • Excel summary of deliverables
  • Electronic data summary outlining analytical method and sample preparation, calibration curve and calculated sample concentrations
  • Rapid turnaround times

Small Molecule Bioanalysis Instrumentation

  • Automated liquid handlers (Tecan) for consistent sample preparation
  • Xevo G2-XS Qtof/Tof
  • Xevo G3 QTof
  • Xevo TQ-S triple quadrupole
  • Multiple Sciex 4000, 5500 QTRAP and 4500 triple quadrupole 
  • QTrap MS/MS systems with Shimadzu Nexera or Waters Acquity UHPLC systems for high sensitivity analysis

Want more information?

Find out more about methods, equipment, timeline expectations, and non-regulated capabilities of our designated Analytical Services department

State-of-the-art Tecan instrumentation used by SEKISUI XenoTech scientists

Emphasis on Quality

Read more about bioanalytical method validation, reporting, and regulatory compliance in our bioanalytical studies

XenoTech Global Headquarters in Kansas City (USA)