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Test Systems & Methods

As test systems become introduced and subsequently vetted by CROs and the scientific community for value and utility in quality, predictive assays, we compile relevant studies and research relating to those which are commonly used or suggested by regulatory authorities for in-house testing. To view our available test systems and reagents, visit our DMPK Test Systems page.

 

Publications

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Bile acid synthesis plays a key role in regulating whole body cholesterol homeostasis. Transcriptional factor EB (TFEB) is a nutrient and stress-sensing transcriptional factor that...
Webinars

Hyaluronan (HA) Synthesis Inhibition Normalizes Hepatic Fibrogenic Features by Reducing Hepatic Stellate Cell Activation in Alcohol-Associated Liver Disease Models

Presenters: Michele Pritchard, Ph.D., Associate Professor, University of Kansas Medical Center and Maciej Czerwinski, Ph.D., Director of Consulting, SEKISUI XenoTech In 2018, Dr. Pritchard published...
Webinars

ADME 101: Biobank Fatty Liver Disease Tissues and Their Exploration in Microarrays

Presenter: Maciej Czerwinski, Ph.D., SEKISUI XenoTech Director of Consulting This ADME 101 discusses biobank tissue and its research applications. The Research Biobank was established to...
Blog

Drug-Drug Interaction (DDI) Prediction Models Following In Vitro Studies in Preclinical Development

In preclinical development, a drug will be evaluated for potential to cause a drug-drug interaction (DDI) using in vitro experiments and then calculations that...

Blog

Toxicokinetic (TK) Analysis for Preclinical Drug Development

The main goal of preclinical toxicokinetic (TK) studies is to establish a correlation between a candidate compound’s concentration or dose...

Webinars

ADME 101: Which Hepatocyte Test System Should I Use?

Presented by Chris Bohl, Ph.D., Global Technical Support Manager This ADME 101 video provides an overview of different types of hepatocytes, their unique benefits, and...
Webinars

ADME 101: Guide to Subcellular Fractions and When to Use Which Test System

Presenter:  Chris Bohl, Ph.D., Global Technical Support Manager This ADME 101 video provides an overview of different types of subcellular fractions, such as microsomes, S9,...
Blog

New TMPRSS2-Expressing Cell Line for COVID-19 Research

We are offering a brand new cell line to assist researchers in the fight against COVID-19.The cell line (JCRB1819), developed...

Blog

What is ADME and how does it fit into drug development?

The main aim of drug development is to get a compound that has a therapeutic effect into the form of...

Webinars

ADME 101 FAQ: Tips & Tricks for Working with Plateable Hepatocytes

Presenter: Halee McElhaney, SEKISUI XenoTech Team Lead, Quality Control In the latest installment of ADME 101, one of our hepatocyte experts answers frequently asked questions...
Publications

Effects of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and interferon-α2a on P450 enzymes in human hepatocytes in vitro

Maciej Czerwiński, Krystal Gilligan, Kevin Westland, Brian W. Ogilvie Some immunomodulatory agents stimulate the release of cytokines capable of suppressing P450 enzymes and potentially affecting pharmacokinetics of coadministered medications. Cytokines...
Blog

How to Choose the Right Test Systems for Your DMPK Studies

Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...

Scientific Posters

CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...
Scientific Posters

CYP1A2 enzyme localization in normal and diseased pediatric livers

Presented at the 55th Congress of European Societies of Toxicology (EUROTOX 2019) in Helsinki, Finland Full Poster Title “CYP1A2 Enzyme Activity and Protein Abundance In Normal...
Blog

Cypex Adds Recombinant UGTs

Recombinant enzymes represent a useful test system for studies requiring extra high levels of catalytic activity. Due to high customer demand, Cypex has...

Scientific Posters

Human mAb stability and cytotoxicity in rat hepatocytes with a surrogate peptide approach

Evaluating stability and cytotoxicity ofHuman monoclonal antibody in cultured rat hepatocytes with a surrogate peptide approach Presented at the 12th International ISSX Meeting in Portland,...
Blog

Make the Most of Your Media

Getting reliable, reproducible results from studies using hepatocytes as a model system for drug metabolism is in part dependent on how well...

Scientific Posters

Human monoclonal antibody stability in rat cell cultures using surrogate peptide LC-MS/MS

Evaluating stability ofHuman monoclonal antibody in rat cell cultures using a surrogate peptide LC-MS/MS approach Presented at the 67th ASMS Conference on Mass Spectrometry &...
Blog

Quality Control is What Makes the Comprehensive Collection of Cell Lines from JCRB Among the Highest Regarded and Most Widely Distributed in the World

About JCRB cell bank In addition to focus on preclinical ADME in vitro testing services and complementary products, SEKISUI XenoTech offers to our...

Blog

Minding Your Binding: Plasma Protein Binding Potential Study Now Available at Our US and Japan Labs

While liver and intestine are important in ADME, behavior in blood is also crucial. When an orally administered drug or...

Scientific Posters

Patterns of hyaluronan deposition in normal and diseased pediatric livers

Presented at the Society of Toxicology (SOT) 58th Annual Meeting & ToxExpo in Baltimore, MD Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele...
Blog

Disease-State Test Systems

SEKISUI XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years...

Blog

Important Considerations for the Conduct of In Vitro Drug Transporter Assays

Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...

Scientific Posters

Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis

Presented at the 2019 AASLD Liver Meeting in San Francisco, CA Authors Dr. Maciej Czerwinski1, Jordan Surgnier2, Dr. Sarah E. Tague3 and Dr. Michele T....
Scientific Posters

Inhibitory effect of typical CYP inhibitors under long term incubation in human liver microsomes

Presented at the 33rd JSSX Annual Meeting / 2018 MDO Meeting in Japan Authors Sho Nishinoaki, Ryo Fujino, Kenta Hashizume, Tsutomu Negama Drug Development Solutions...
Scientific Posters

MALDI-Imaging quantitation of neurotransmitters in rat brain using “Triple Spray” method

MALDI-Imaging quantitation of neurotransmitters in rat brain using “Triple Spray” method Presented at the 33rd JSSX Annual Meeting / 2018 MDO Meeting in Japan Toshimasa...
Webinars

CryostaX Pellets: Improving hepatocyte pooling, activity and lab efficiency

Presenter:  Chris Bohl, Ph.D., Global Technical Support Manager Synopsis: CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows for distinct benefits...
Blog

Cypex Expands Portfolio of Recombinant Enzymes

As the exclusive distributor for Cypex in the US and Canada, SEKISUI XenoTech is proud to offer this portfolio of products based...

Blog

New Rodent, Monkey CryostaX Hepatocytes Featured in Industry News

Following SEKISUI XenoTech’s announcement SEKISUI XenoTech Adds Monkey, Rodent Hepatocytes to Patented CryostaX Product Line, Anticipates the End of Traditionally Cryopreserved...

Scientific Posters

Microsomal cytochrome P450 (CYP) enzyme activities in nonalcoholic steatohepatitis (NASH) livers

Presented at the 22nd North American ISSX Meeting Montréal, Quebec, Canada Authors Maciej Czerwinski1, Brian Oberheide1, Nicholas Hatfield1, Bill Ewy1, Christopher Seib1, Eva Gatineau2, Frederique Yiannikouris2,...
Blog

No-Cost, On-Demand Primary Human Hepatocyte Pooling Using CryostaX Pellets

CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows scientists to easily pool primary...

Blog

NADPH RapidStart Regeneration System for Extended Metabolism

Originally published in tebu-bio’s Being Bioreactive. To purchase SEKISUI XenoTech’s products in the EU, please visit tebu-bio’s website. NADPH is a critical...

Webinars

Patient-Derived Tumor Organoids for Personalized Medicine & Targeted Drug Discovery

Presenter: Motoki Takagi, Ph.D., Professor, Medical-industrial Translational Research Center, Fukushima Medical University Synopsis: Patient-derived tumor organoids (PDOs) are cell aggregates produced by in vitro cell...
Blog

Maximize Metabolic Activities by Limiting Hepatocyte Cryoinjury

Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. Traditional pooling methods require cells to undergo two separate cryopreservation...

Blog

Assess Catabolic Stability of Biologics & ADCs with Lysosomes – Characterized Test Systems

Originally published in tebu-bio’s Being Bioreactive. To purchase SEKISUI XenoTech’s products in the EU, please visit tebu-bio’s website.  Following up on my...

Blog

No More Water Baths! Simplify Hepatocyte Thaws and Eliminate Contamination

SEKISUI XenoTech has patented technology that eliminates the need for the water baths that are traditionally required to thaw cryopreserved hepatocytes. By removing...

Blog

Choosing a Relevant Small Animal Model for Pharmacokinetic or Toxicity Studies

Choosing the most suitable small animal model is crucial for pharmacokinetic and/or toxicology studies in order to get usable, relevant data. Due to potential...

Blog

Recombinant CYP Bactosomes: Versatile Formats for Many ADME Applications

Originally published in tebu-bio’s Being Bioreactive. To purchase recombinant CYPs in the EU, please visit tebu-bio’s website. For North American orders, please follow...

Blog

Insects and Cattle and Sheep, Oh My!

Over the past two decades, we’ve received a lot of interesting requests for custom tissue preparations here at SEKISUI XenoTech....

Publications

In Vitro Products & Reagents Technology Guide

The 2017-2018 Product Technology Guide provides a complete list of SEKISUI XenoTech’s products as well as their uses and applications. This guide also has a...
Blog

What To Do with Microsome Stable Low Turnover Compounds

Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol) can be a challenge for ADME scientists. These in...

Scientific Posters

Comparison of two hepatic uptake assay methods

Authors Akito Takahashi, Ryota Takeuchi, Ryo Fujino, Kenta Hashizume, Shin-ichi Ninomiya Drug Development Solutions Center, Drug Development Solutions Division, Sekisui Medical Co., Ltd. 2117 Muramatsu,...
Blog

Hepatosure Hepatocytes: The Largest Donor Pool For Your DMPK Applications

Pooled human hepatocytes can complement a selection of hepatocytes from various species for metabolite profiling, species comparison and evaluation of potential human-specific metabolites. HepatoSure® is the...

Blog

Cold Storage Solution Linked to Lower AO, XO Activity

At the time of organ recovery, human livers that have been donated for research are flushed with an ice-cold perfusion...

Blog

Considerations When Studying Esterase Activities in the Intestine

The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...

Blog

New range of Pig P450s Bactosomes

If you are looking for enzymatic in vitro tools for drug metabolism, reaction phenotyping or metabolite generation using a pig model, you may find these newly...

Blog

New Liver Disease Resource and Other Research Biobank News

SEKISUI XenoTech is committed to furthering the knowledge surrounding hepatic diseases, which affects one out of four people worldwide, such...

Blog

Big Hepatocyte News!

As you may have heard, SEKISUI XenoTech was issued U.S. Patent No. 9,642,355 for the “CRYOPRESERVATION OF CELLS AND SUBCELLULAR FRACTIONS” for its CryostaX® hepatocytes....

Scientific Posters

Hepatocytes as the preferred test system to evaluate oligonucleotide-CYP Interactions in vitro

SEKISUI XenoTech previously examined the potential of oligonucleotides to inhibit cytochrome P450 (CYP) and reported that the phosphorothioate, but not phosphodiester, backboned molecules caused potent...
Blog

SEKISUI XenoTech Adds New Dermal Subcellular Fraction Test Systems

SEKISUI XenoTech is adding human and minipig to the company’s list of species with dermal subcellular fractions available as standard test systems for the...

Scientific Posters

Research collection of variants of normal and fatty liver disease in human livers

SEKISUI XenoTech has developed a Research Biobank that is a collection of normal, steatosis and steatohepatitis tissue samples gathered and characterized to facilitate the study...
Scientific Posters

Evaluation of the CYP metabolic activities in the presence of albumin in human liver microsomes

Cytochrome P450 (CYP) isoforms are responsible for the metabolism of the majority of drugs in human. An intrinsic clearance (CLint) determined from in vitro intrinsic...
Scientific Posters

Evaluation method for mitochondrial toxicity using Crabtree effect

Mitochondria plays a crucial role in living organisms, one of which being the synthesis of ATP. Mitochondrial toxicity is widely tested as part of the...
Blog

SEKISUI XenoTech Standardizes Lysosomal Test Systems for Biopharmaceutical Development

Before releasing these test systems, there was not a high quality, specific, relevant, easy and ready to use, in vitro test system to...

Webinars

Adverse drug interaction risks in genetically-definied

Presenter:  Maciej Czerwinski, Ph.D., Director of SEKISUI XenoTech Products R&D Synopsis: An increased appreciation of the effects of genetic variability on the pharmacokinetic and pharmacodynamic properties of xenobiotics creates a...
Webinars

Tritosomes and Lysosomes for Characterization of Biologic Drugs

Presented by Dr. Chris Bohl, Manager of Techical Support, Products Synopsis Tritosomes and Lysosomes for Characterization of Biologic Drugs: Investigation of freshly purified rat tritosomes...
Scientific Posters

Automated High Content Drug Transport Screening with Transwell Plates for Drug Discovery

The purpose of this study was to develop a method to use bidirectional intestinal permeability and drug transport to identify substrates and inhibitors of MDR1...
Scientific Posters

In vitro characterization of human liver lysosomes isolated from fresh tissue

Evaluation of lysosomal catabolism is an integral part of the development of biologic drugs including antibody-drug conjugates (ADC). Biologics can enter the cell by fluid-phase...
Scientific Posters

Efficient use of chimeric mice with humanized livers for drug development support

Chimeric mice withHumanized livers can be used to obtain supportive data for selecting the best candidate compound for new drug development. To utilize this costly...
Scientific Posters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Human ABC Transporters P-gp

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Human ABC Transporters P-gp and BCRP in Membrane Vesicles P-gp (ABCB1/MDR1) and BCRP (ABCG2) are...
Scientific Posters

Comparison of Ki and IC50 Values for Prototypical Inhibitors

Comparison of Ki and IC50 Values for Prototypical Inhibitors of ABC Transporters P-gp and BCRP Ki values were determined for prototypical inhibitors of ABC transporters...
Scientific Posters

Automated Plasma Protein Binding Using Rapid Equilibrium Dialysis

High Content Automated Plasma Protein Binding Screening and Definitive Assays Using Rapid Equilibrium Dialysis for Drug Development A pharmacokinetic/pharmacodynamic principle important in drug development is...
Scientific Posters

Rapid mRNA Induction Screen

A Rapid High Content Cytochrome P450 (CYP) mRNA Induction Screen for Early Drug Development Cytochrome P450 (CYP) enzymes play an important role in the oxidative...
Scientific Posters

Effects of Various Media

The Effect of Buffer Ionic Strength or Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates in PooledHuman Liver Microsomes and CryopreservedHuman Hepatocytes...
Scientific Posters

Assessment Under Initial Rate Conditions

Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in PooledHuman Liver Microsomes and Hepatocytes: Optimization of Inhibitor Conditions...
Scientific Posters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters We previously reported on the similarities and differences in Ki and IC50 values for various inhibitors...
Scientific Posters

In Vitro System-Dependent Inhibition

In Vitro System-Dependent Inhibition of Cytochrome P450 Enzymes (CYP), UDP-Glucuronosyltransferases (UGT) and Transporters by Oligonucleotides We previously examined the cytochrome P450 (CYP) inhibition potential of...
Scientific Posters

The Impact of Incomplete Dose-Response Curves on EC50 and Emax Determinations in Enzyme Induction

The Impact of Incomplete Dose-Response Curves on EC50 and Emax Determinations in Enzyme Induction Assessment In evaluating the enzyme induction potential of a new drug...
Scientific Posters

Pooled Plated Cryopreserved Human Hepatocytes

The Use of Pooled Plated CryopreservedHuman Hepatocytes for the Determination of Metabolic Clearance, Cytochrome P450 Enzyme Induction and Uptake Transporter Studies During early drug discovery...
Scientific Posters

SLAS 2014 – Automated Metabolic Stability

High content automated metabolic stability and CYP inhibition cocktail screening assays for early drug development. The assessment of metabolic stability and cytochrome P450 (CYP) inhibition...
Scientific Posters

ISSX 2013 – S9 Long-Term Storage

Human liver S9 fractions stored at -70°C maintain high phase I and phase II enzymatic activities over multiple freeze/thaw cycles and for at least 10...
Scientific Posters

ISSX 2013 – Cytokines in Kupffer Cells

Endotoxin up-regulates the proinflammatory cytokines TNF-α and IL-6 in freshly-isolated human Kupffer cells. Kupffer cells, macrophages endogenous to the liver, can modulate hepatic inflammation and...
Scientific Posters

ISSX 2013 – Comparing Ki and IC50 Values

Comparison of Ki and IC50 values for prototypical and clinically-relevant probe substrates of the hepatic transporters OATP1B1 and OATP1B3 Organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1,...
Webinars

Aldehyde Oxidase: Why In Vitro Absolute Activity Doesn’t Matter

Presented by: Brian Ogilvie and Faraz Kazmi Biotransformation by aldehyde oxidase (AO) is an important clearance mechanism for many drugs and drug candidates, with increasing...
Publications

Exploring the Utility of High-Resolution MS with Post-Acquisition Data Mining for Simultaneous Exogenous and Endogenous Metabolite Profiling

Exploring the Utility of High-Resolution MS with Post-Acquisition Data Mining for Simultaneous Exogenous and Endogenous Metabolite Profiling Presented by: Barbara JE, Buckley DB, Horrigan MJ...
Publications

Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 cells)

Kazmi F, Hensley T, Pope C, Funk RS, Loewen GJ, Buckley DB, Parkinson A Lipophilic (logP > 1) and amphiphilic drugs (also known as cationic...
Webinars

Application of Hepatocytes for In Vitro Uptake Assays

Presented by: David Buckley, Ph.D. – CSO This webinar provides a basic review of concepts applicable to a structure-based approach for the evaluation of hepatic...
Publications

High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs During In Vitro Metabolite Profiling

Presented by: Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A In vitro metabolite profiling and characterization experiments are widely employed in early drug...
Scientific Posters

A robust method to identify compounds that undergo intracellular lysosomal sequestration

Lysosomes are acidic organelles (pH 4-5) that play a key role in various metabolic processes such as turnover of phospholipids, the breakdown of waste products...
Scientific Posters

Evaluation of dilution, dialysis and ultracentrifugation methods to assess the reversibility of metabolism-dependent inhibitors (MDIs) of cytochrome P450 (CYP) enzymes

Evaluation of dilution, dialysis and ultracentrifugation methods to assess the reversibility of metabolism-dependent inhibitors (MDIs) of cytochrome P450 (CYP) enzymes Metabolism-dependent inhibition (MDI) of P450...
Scientific Posters

Temporal changes in CYP3A4 mRNA and activity following treatment of cultured human hepatocytes with interleukin-6 (IL-6): Implications for study design and endpoint selection

Temporal changes in CYP3A4 mRNA and activity following treatment of culturedHuman hepatocytes with interleukin-6 (IL-6): Implications for study design and endpoint selection In recent years...
Scientific Posters

Evaluating the potential for lysosomal trapping in immortalized human hepatocytes (Fa2N-4 cells)

Evaluating the potential for lysosomal trapping in immortalizedHuman hepatocytes (Fa2N-4 cells) Sequestration of high concentrations of lipophilic amines (a.k.a cationic amphiphilic drugs or CADs) in...
Publications

Comprehensive Quantitative and Qualitative Liquid Chromatography–Radioisotope–Mass Spectrometry Analysis for Safety Testing of Tolbutamide Metabolites Without Standard Samples

Zenzaburo Tozuka, Shinsuke Aoyama, Kohei Nozawa, Shoji Akita, Toshinari Oh-Hara, Yasuhisa Adachi, Shin-Ichi Ninomiya ADME & Tox. Research Institute, SEKISUI Medical Company, Ltd., Tokai, Ibaraki...
Scientific Posters

The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes

Cryopreserved hepatocytes provide a convenient in vitro test system to study the phase-1 and phase-2 metabolism of new chemical entities; however cryopreservation (freeze-thaw cycles) can...
Scientific Posters

Accurate mass spectrometry elucidates a misleading metabonate formed from amine-containing drugs in reactive metabolite screening assays

Accurate mass spectrometry elucidates a misleading metabonate formed from amine-containing drugs in reactive metabolite screening assays The propensity of drug candidates to undergo cytochrome P450...
Scientific Posters

In situ evaluation of CYP1A2, CYP2B6 and CYP3A4/5 induction in cultured human hepatocytes with a cocktail of probe substrates: A comparison of percent positive control values

It has previously been demonstrated that a cocktail of probe substrates can be effectively used to screen simultaneously for induction of CYP1A2, CYP2B6 and CYP3A4/5...
Scientific Posters

The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes

The effect of multiple cryopreservation cycles on drug-metabolizing enzymes inHuman hepatocytes Cryopreserved hepatocytes provide a convenient in vitro test system to study the phase-1 and...
Scientific Posters

Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to Underestimation of the Shifted IC50 Value

We previously demonstrated that, when a dilution step is used to assess MDI potential (i.e., IC50 shift experiments), IC50 values for direct-inhibition and MDI should...
Scientific Posters

Effects of Gender, Age and Ethnicity on Human Cytochrome P450 Activity

Introduction It has been well documented that the expression of CYP enzymes is influenced by endogenous factors, such as genetic polymorphisms and hormone levels, and...
Scientific Posters

Microsomes and S9 Prepared from Renal Tissue Yield High CYP, FMO and UGT Activities that are Stable…

Microsomes and S9 Prepared from Renal Tissue Yield High CYP, FMO and UGT Activities that are Stable over Multiple Freeze/Thaw Cycles Abstract We have developed...
Scientific Posters

Cytochrome P450 3A4 and 1A2 Induction in Immortalized and Primary Cultures of Human Hepatocytes

Cytochrome P450 3A4 and 1A2 Induction in the Immortalized Hepatocyte Line, Fa2N-4, and Comparison with Primary Cultures ofHuman Hepatocytes Abstract Primary cultures ofHuman hepatocytes are...
Scientific Posters

Microsomes Prepared from Eluted Enterocytes Yield High Cytochrome P450 and UGT Activities that are…

Microsomes Prepared from Eluted Enterocytes Yield High Cytochrome P450 and UGT Activities that are Stable over Multiple Freeze/Thaw Cycles Abstract Enterocytes in the upper region...
Scientific Posters

The Use of Immortalized Hepatocytes in Induction Studies

Introduction Primary cultures of human hepatocytes are widely used to evaluate the cytochrome P450 (CYP) enzyme-inducing potential and/or toxicity of drug candidates. However, the availability...