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Posts by category
- Category: Accomplishments
- Updated Look & Fresh Features: Welcome to Our Brand New Website!
- XenoTech Named Most Innovative Drug Development Solutions Provider – USA 2020
- COVID-19 Updates
- KC Business Journal: KCK company helps Big Pharma save money at the molecular level
- XenoTech Named Best In Vitro Drug CRO 2019
- The Story of Us
- XenoTech Named Best In Vitro Drug Metabolism Studies Provider 2018
- XenoTech Featured in Fall Issue of NewsWave
- XenoTech Named Best for Pharmaceutical Safety Testing 2017
- XenoTech Fulfills Largest Order To Date
- Category: ADME 101™
- FAQ: Using Plateable Hepatocytes in In Vitro Assays
- Ask Me Anything About In Vitro ADME, Drug-Drug Interaction Approaches and Strategies
- Are in vitro drug metabolism and drug-drug interaction studies critical for an IND?
- 4 Ways De-Risking Maximizes Compound Value
- Which Hepatocytes Should I Use for What Studies?
- What is DMPK and how does it fit into drug development?
- ADME and Drug-Drug Interactions for the Toxicologist
- What is ADME and how does it fit into drug development?
- In Vitro Evaluation of Drug-Drug Interaction (DDI) Potential
- Four ways to optimize preclinical in vitro data to mitigate risk of late-stage clinical failure
- How can in vitro and in vivo studies help me understand my drug’s clearance?
- Timing of In Vitro Studies: Early, Thorough ADME for Your Compound’s Success
- How Can I Make Sure My Data Meets Regulatory Expectations?
- What In Vitro Metabolism and DDI Studies Do I Actually Need?
- I Have My Data… Now What?
- The FDA has requested follow-up data… how do I fill in the gaps?
- How to Choose the Right Test Systems for Your DMPK Studies
- Category: Biologics & Oligonucleotides
- Can Interactions Between Therapeutic Proteins and Small Molecule Drugs Be Evaluated In Vitro?
- October Presentations on In Vitro Effects of Biologics on CYP Enzymes and Regulatory DDI Guidances
- Response to FDA Framework for Assessment of Drug-Drug Interactions for Therapeutic Proteins RFI and Comments
- Assess Catabolic Stability of Biologics & ADCs with Lysosomes – Characterized Test Systems
- New Lysosome Catabolism Protocol and Tech Tips
- Category: Consultancy
- Guide to When & Why to Evaluate ADME/DMPK & Drug-Drug Interactions Available
- Four Ways CROs Drive Innovation for Improved In Vitro Drug Metabolism and Pharmacokinetics (DMPK) Studies
- DDI & Drug Repurposing Article featured in Drug Discovery World (DDW) Spring Edition 2021
- Interview with Outsourcing Pharma: Repurposing existing drugs accelerates discovery
- Important DDI Considerations for Repurposing Drugs to Treat COVID-19
- Meet the Scientist: Pallavi Limaye
- Consultancy Expansion
- New VP of Scientific Operations and VP of Scientific Consulting
- Category: Disease-Specific Resources
- Category: Drug Drug Interactions (DDI)
- New FDA Draft Guidance “Clinical Pharmacology Considerations for the Development of Oligonucleotide Therapeutics” – XenoTech’s perspective on in vitro DDI testing
- Spotlight on Efflux and Uptake Drug Transporters in In Vitro Drug-Drug Interaction Studies
- When, Why and How to Conduct CYP2C Induction Studies
- Why Do Most Polled Researchers Run Red Blood Cell Partitioning Studies with Plasma Protein Binding?
- Highlights from the 2021 Marbach Drug-Drug Interaction Workshop
- 2021 Service Expansions: Microsomal Protein Binding and Red Blood Cell Partitioning
- ADME/PK & DDI Best Practices Industry Survey Results & Infographic
- Drug-Drug Interaction (DDI) Prediction Models Following In Vitro Studies in Preclinical Development
- Transporters of Emerging Importance in Drug Development: Beyond the Guidance Documents
- In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis
- Minding Your Binding: Plasma Protein Binding Potential Study Now Available at Our US Labs
- Important Considerations for the Conduct of In Vitro Drug Transporter Assays
- To GLP or not to GLP?
- In Vitro DDI Regulatory Guidance Reference Poster
- Further Research on the Drug-Drug Interaction Between Gemfibrozil and Repaglinide Presented
- Considerations In Response to Drug-Drug Interaction Guidances
- XenoTech Scientists Publish Paper, Present Research Evaluating Ketoconazole and its Alternative Clinical CYP3A4-5 Inhibitors as Inhibitors of Drug Transporters
- Category: Drug Metabolism
- Can CYP3A4 Induction Predict P-glycoprotein Induction in DDI Studies?
- NADPH RapidStart Regeneration System for Extended Metabolism
- Maximize Metabolic Activities by Limiting Hepatocyte Cryoinjury
- Recombinant CYP Bactosomes: Versatile Formats for Many ADME Applications
- What To Do with Microsome Stable Low Turnover Compounds
- HepatoSure Hepatocytes: The Largest Donor Pool For Your DMPK Applications
- Cold Storage Solution Linked to Lower AO, XO Activity
- Considerations When Studying Esterase Activities in the Intestine
- Category: Drug Transporters
- Interesting Topics at the 3rd SCI-RSC Symposium on Transporters in Drug Discovery and Development
- Reduced Pricing for In Vitro Transporter Studies
- Coverage from the October 2018 PBSS DDI Workshop
- New Recommendation: Evaluate NMEs for OCT1 Transporter-Mediated DDI Potential
- Challenges & Solutions in Today’s In Vitro Transporter Research
- AAPS-FDA Drug Transporters
- XenoTech Adds US Support for MATE1 and MATE2-K Drug Transporter Studies
- URI Drug Transporters Workshop Presentations
- XenoTech Adds New Drug Transporters to Portfolio
- Navigating the Transporter Wave of 2013
- Category: Enzyme Induction
- Category: Enzyme Inhibition
- Category: In Vivo & Radiolabeling
- Toxicokinetic (TK) Analysis for Preclinical Drug Development
- Missing Out on Annual ‘Comforting of the Soul’
- What You Need to Know About Micro-Autoradiography (mARG) Distribution Studies
- DDSC In Vivo ADME Expertise Providing Cost Savings
- Mass Balance Studies: What You Need and Why You Need It
- Why You Need QWBA for Human Radiolabeled ADME Studies
- In Vivo ADME: What You Need and Why You Need It
- Studies in Japan: Easier & More Beneficial than You Might Think
- Choosing a Relevant Small Animal Model for Pharmacokinetic or Toxicity Studies
- Category: Meet the Scientist
- Meet the Scientist: Alex Wakefield
- Meet the Scientists: Program Execution
- Meet the Scientists: Analytical Services’ Chandra Kollu & Nadya Galeva
- Meet the Scientist: Darina Hynes
- Meet the Scientist: Stephanie Helmstetter
- Meet the Scientist: Lois Haupt
- Meet the Scientist: Andrea Wolff
- Meet the Scientist: Mark Horrigan
- Category: Non-CYP Enzymes
- Category: Our Team
- Category: Regulatory Guidance
- Category: Test Systems & Methods
- Notes from the 2021 HRA Expert Panel Discussion “Are Standard Hepatocyte Models/Test Systems Still Good Enough?”
- Why Switch to Hepatocyte Pellets?
- Cypex Adds Recombinant UGTs
- Cell Handling & Media Selection for Best Results in Hepatocyte Assays
- Quality Control is What Makes the Comprehensive Collection of Cell Lines from JCRB Among the Highest Regarded and Most Widely Distributed in the World
- New Rodent, Monkey CryostaX Hepatocytes Featured in Industry News
- No-Cost, On-Demand Primary Human Hepatocyte Pooling Using CryostaX Pellets
- No More Water Baths! Simplify Hepatocyte Thaws and Eliminate Contamination
- Insects and Cattle and Sheep, Oh My!
- New range of Pig P450s Bactosomes
- Big Hepatocyte News!
- XenoTech Adds New Dermal Subcellular Fraction Test Systems
- XenoTech Standardizes Lysosomal Test Systems for Biopharmaceutical Development
- Category: Updated Offerings
- XenoTech Named a 2019 Top-Performing Provider on Science Exchange
- XenoTech Named Best for Drug Candidate Evaluations 2019, Leading Providers of Pharmaceuticals Safety Testing
- 5 Keys to Set Your Contract Research Organization (CRO) Collaboration Up for Success
- Holiday CSR Activities
- XenoTech Named Best Global CRO 2018; Recognised Leaders in Pharmaceutical Safety Testing 2018
- XenoTech Hiring and Growing to Meet Customer Demand
- XenoTech’s Analytical Services Department Adds Instrumentation
- Category: Tox
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- CYP010
- CYP206
- C2E1BR020C
- CYP/EZ029
- 2010171
- 2010160
- 2010159
- BAC100B
- C2A6BR011
- 2010066
- D1000.IC
- M1000.RC
- M2000.S9
- M2000
- M1500.C
- M1000
- CYP532-25
- CYP534
- CYP535
- 512
- HC2-48
- HC2-26
- HC10-18
- HC7-14
- HC5-24
- HC5-20
- HC4-6
- HC4-14
- HC10-12
- 1610329
- R1000.IS9
- 2010191
- R3000.C
- R1500.S9
- R1500.C
- R1000.C
- H640
- HC3-23
- HC5-9
- HC5-17
- HC5-12
- HC3-5A
- HC3-43
- HC3-42
- HC10-20
- P2000.RS9
- P2000.PS9
- 2010076
- P2500.S9
- P2500.C
- HC7-31
- HC5-14
- HC5-10
- HC3-7
- HC3-3A
- HC2-7
- HC2-47
- Clearance H1000.H15C
- Z6000.C
- CYP038
- D1500
- D1000.C
- 2010074
- 1810265
- CYP520
- CYP531-10
- CYP525
- CYP527-10
- CYP526
- CYP522-25
- CYP522-10
- CYP529-10
- CYP516
- CYP515-25
- CYP533
- CYP515-10
- 512001
- CYP512
- CYP510
- CYP505
- CYP500-5
- 0810405
- 0710238
- 0210294
- Clearance H2620.S9 Lots
- 2010189
- D1000.H15
- 2010125
- 1910063
- 2010132
- 0710487
- 1610303
- 1510071
- 1310046
- 2010058
- 1910195
- 2010022
- 0810064
- 0710330
- 0610395
- 1810092
- 1910210
- 1910211
- 1910166
- 0810444
- 2010027
- 2010026
- 0610090
- 0810436
- 2010013
- 2010154
- 1910196
- 2010070
- 2010150
- 1910202
- 20-1-0257
- 20-1-0331
- 19-1-0628
- 20-1-0303
- 20-1-0153
- 20-1-0347
- 20-1-0249
- 1910219
- 1810130
- 1110377
- 2010071
- 0710456
- 0810405
- 1910096
- HC3-51
- HC7-1
- 0710493
- 2010065
- 2010065
- 2010065
- 1210097
- 2010128
- 2010163
- 1610313
- 2010065
- 0810039
- 2010046
- RUS 0488
- INT071E17
- C2D6*17LR003
- C2C19BR021
- C2B6BR050
- C2C9BR013B
- C2D6*2R004/B
- C3A4BR052B
- C1A2R013
- PPCH2000
- LPCH1500
- K8650
- CYP073
- CYP/EZ073
- CYP064
- CYP046
- INT044E6B
- CYP108
- INT044E2B
- CYP104
- CYP207
- 1010062
- 1410242
- 0910452
- 1910190
- 1010064
- 0310184
- 0310186
- 0310181
- 0310183
- 1710032
- 1810266
- 1910053
- 1910005
- 1810054
- 1910004
- 1810267
- 1810053
- 1810055
- 1210377
- 0710394
- 0710395
- 1210379
- 1810168
- 1810167
- 1810166
- 1810247
- 0910367
- 0810332
- 1610349
- 1610230
- 1210411
- 1210246
- 1610231
- 1610229
- 1810173
- 1110544
- 0610167
- 0610169
- 0610168
- 0010183
- 0610097
- 0510017
- 1610248
- 1610030
- 1210257
- 1610292
- 1210326
- 1110064
- 0810396
- 0810395
- 1010125
- 1910135
- 1310228
- 0910241
- 0410207
- 0410208
- 1010255
- 1010046
- 0610242
- 0610243
- 1010047
- 0610244
- 0210107
- 1110039
- 1710044
- 1510131
- 1510028
- 0810450
- 1310205
- 1110040
- 0810451
- 0510066
- 1710036
- 1210084
- 1110155
- 0510064
- 1110154
- 1510257
- 1810063
- 0310131
- 1010045
- 0610282
- 0510053
- 0610080
- 1710232
- 1310185
- 1010154
- 1310186
- 1010155
- 1510046
- 1110446
- 1310033
- 1710099
- 1510047
- 1110008
- 1010153
- 1610307
- 1410151
- 1810136
- 1410152
- 1310076
- 1210435
- 1410153
- 1810129
- 1710040
- 1510219
- 1810006
- 1710151
- 1710122
- 1710038
- 1610409
- 1610332
- 1610291
- 1610085
- 1510332
- 1510093
- 1110457
- 1110186
- 1710082
- 1610132
- 1510346
- 0810201
- 0510131
- 1110136
- 1110137
- 1910193
- 1410273
- 1310213
- 1910100
- 1710161
- 1910121
- 1810077
- PR10026
- PR10025
- PR10024
- PR10022
- PR10023
- PR10021
- 1210448
- 1310011
- 1210031
- 1210449
- 1210450
- PR10020
- PR10019
- PR10018
- PR10016
- PR10017
- PR10015
- 1610267
- 1510192
- 1310273
- 1010320
- 1510139
- 1110468
- 1510138
- 1110469
- 1010178
- 0810074
- 1210292
- 1210293
- 1110024
- 1010187
- 0810014
- 0310239
- 1710098
- 1710034
- 1110388
- 0510273
- 0510141
- 1510022
- 1410046
- 1810276
- 1510021
- 1710035
- 1110390
- 1110172
- 1610269
- 1610037
- 1210333
- 1110342
- 1910165
- 1810093
- 1610045
- 1310274
- 1810292
- 1810275
- 1810061
- 1810067
- 1510350
- 1510057
- 1510352
- 1810172
- 1310126
- 0810496
- 0810025
- 1810163
- 0810497
- 1010427
- 1010428
- 1310222
- 1010108
- 1510135
- 1510104
- 1710054
- 1510135
- 1510104
- 1410291
- 1410269
- 1210349
- 1010109
- 1410027
- 1310224
- 1010110
- 1510255
- 1310026
- 1110521
- 1010123
- 0810364
- 1310040
- 1310044
- 1310043
- 0510196
- 1310042
- 1610235
- 1310021
- 1210473
- 1810091
- 1510142
- 1610408
- 1810011
- 1710136
- 1710075
- 1710006
- 1610436
- 1610228
- 1610186
- 1510347
- 1510134
- 1510010
- 1810005
- 1110114
- 1810051
- 1110115
- 2010017
- 1510256
- 1010271
- 1010093
- 1610310
- 1210410
- 1010272
- 1010094
- 1010273
- 1010095
- 1210284
- 0710108
- 1610309
- 1610041
- 1210372
- 1110135
- 1210286
- 0510023
- 1610101
- 0810371
- 20-1-0342
- 1610342
- 1910008
- 1810032
- 1910093
- 0910051
- 0910052
- 0810011
- 0810010
- 0710410
- 0710411
- 0710415
- 0710414
- 0810002
- 0710412
- 1910146
- 1410252
- 1310290
- 1210253
- 1910006
- 1810050
- 1910187
- 1710177
- 1810126
- 1510101
- 1510254
- 1510253
- 1510251
- 1510250
- 1510230
- 1510228
- 1510233
- 1510232
- 1510231
- 1510252
- 1510237
- 1510236
- 1510235
- 1510234
- H1293
- H1288
- H1294
- 1810234
- 1810041
- 1810084
- 1810085
- 2010012
- 1910001
- 1810179
- 1710168
- 1610128
- 1210265
- 1210188
- 0710253
- 0710252
- 0710234
- 0710233
- 0010082
- 1510202
- 1510201
- 1510200
- 0710461
- 0810010
- 0710445
- 0710443
- 0710420
- 0810006
- 0710457
- 0710456
- 0710455
- 0710450
- 0710446
- 0710442
- 0710425
- 0710421
- 0710415
- 0710413
- 1710127
- 1710126
- 1710125
- 0710428
- 0710427
- 0710439
- 0810010
- 0710415
- 0710450
- 0710444
- 0910256
- 1910096
- 1710084
- 0910312
- 1610440
- 1410228
- 1110370
- 1910096
- 1710084
- 1610440
- 1410228
- 1110370
- 0910256
- 1910096
- 1710084
- 0910256
- 0810405
- 1410229
- 1210404
- 0910313
- 1710084
- 1010420
- 0610234
- H706
- 611
- 512
- HC3-38
- HC3-26
- HC5-55
- HC5-29
- HC4-38
- HC4-15
- HC2-50
- HC2-31
- HC10-55
- HC10-52
- HC10-50
- HC10-42
- HC10-23
- HC10-1
- 527
- HC5-6
- HC3-41
- HC2-48
- HC2-28
- HC2-26
- HC1-10
- HC10-18
- H0864
- HC5-40
- HC3-47
- HC3-30
- HC2-39
- HC2-19
- HC1-30
- HC7-14
- HC5-34
- HC5-24
- HC5-20
- HC4-6
- HC4-24
- HC4-14
- HC3-21
- HC10-12
- H886
- H877
- H789
- HC2-18
- H683
- H640
- 0710245
- 0610370
- 1210079
- 1210268
- 0710492
- H694
- HC7-4
- HC7-33
- HC7-29
- HC7-25
- HC2-35
- HC1-34
- HC10-49
- HC10-45
- HC0-12
- HC7-31
- HC5-14
- HC5-10
- HC4-5
- HC3-7
- HC3-3A
- HC2-7
- HC2-47
- HC4-25
- HC4-20
- HC3-37
- HC3-15
- HC2-25
- HC1-35
- HC0-9
- HC0-2
- HC0-10
- HC5-9
- HC5-27
- HC5-17
- HC5-12
- HC3-5A
- HC3-43
- HC3-42
- HC10-20
- HC3-5
- HC3-23
- 1210269
- 1210270
- 0710494
- 1210091
- 0810471
- 1810003
- 1810001
- 1610015
- 1810003
- 1810001
- 1610015
- 1810003
- 1810001
- 0910396
- 1410118
- 0510093
- 1310121
- 1710160
- 1410121
- 1110009
- 0710282
- 1410122
- 1310100
- 1910176
- 1310176
- 1910175
- 1210126
- 1710039
- 1310201
- 1410073
- 1410065
- 1610315
- 1410066
- 1610314
- 1510072
- 1910164
- 1610320
- 1810002
- 1810003
- 1110473
- 1710129
- 1010191
- V8
- 0710355
- 0710093
- 0910275
- 0710094
- 0510021
- 0610384
- 1210438
- 1010341
- 0610385
- 1310105
- 072800A
- 0510078
- 0510074
- 0510075
- 080100D
- 080700C
- 1310285
- 0810316
- 1010362
- 0310051
- 1810236
- 0810037
- 1810237
- 0710519
- 1110253
- 0710285
- 0210292
- 1210049
- 1110254
- 1910147
- 1210287
- 1110092
- 1010188
- 0810039
- 0210294
- 1410280
- 1310232
- 1310233
- 1310161
- 1610242
- 1410279
- 1310234
- 1910037
- 1710019
- 1810069
- 1610293
- 1710018
- 1410115
- 532001
- 530001-10
- 529001-25
- 09062006
- 527001-25
- KCO2018-1000
- KCO2018-100
- 107-100
- RUS 0543
- RUS 0535
- RUS 0474
- RUS 0488
- RUS 0460
- RUS 0434
- RUS 0399
- RUS 0398
- 501005
- 501007
- INT001E5
- BINT068E24
- INT068E14
- INT068E7
- INT068E6
- INT062E4A
- INT062E1
- INT055E2
- INT066E2B
- INT066E1C
- INT062E2
- INT061E3
- INT061E2
- INT061E5
- INT059E6
- INT059E5
- INT059E4
- INT059E3
- INT059E2
- INT059E7
- INT062E3A
- DC1A2LR001
- INT043E7D
- INT043E6C
- DC2D15LR001
- INT043E4B
- DC2C21LR001/A
- DC2B11LR001/A
- INT043E1
- INT070E5A
- INT070E4A
- INT070E3A
- INT070E2A
- INT070E1B
- INT045E31
- INT063E37
- INT063E33
- 153015B
- 152006B
- 152006A
- INT046E6A
- 150011B
- INT029E5B
- GSTA1001A
- INT044E5/A
- INT044E4A
- INT044E3A
- INT044E4A
- INT044E1B
- INT033E10A
- S1A3003A
- S1A1*1001-A
- INT016E18C
- INT016E18-B
- C17A1R002
- C17A1LR003A
- C2C19BR018
- C2C19BLR008
- C2B6BLR003
- C3A7BR003
- INT050E2
- C4F3BBR001
- C4F3BBLR001
- C4F3BR001
- C4F3BLR001
- C3A7BLR002
- C2C8BLR001
- C3A5BR001
- C2C8LR002
- C3A5BLR009
- BINT034E2A
- C4A11BR003
- C2C9*2BR001
- C2B6BR041
- INT039E10
- INT034E1A
- C2C9BHR024
- C2E1BR019
- C3A4BLR007
- C2J2LR006
- C2A13R001/A
- INT037E2
- INT034E7
- C2D6*39R001A
- INT030E29
- C2C19LR005
- C2C19LR004
- C2D6*2R003
- INT027E5A
- C4A11LR002
- C4A11LR001
- C1B1*4LR001A
- INT021E12
- C1B1LR001
- C2C18LR001A
- INT013E12
- C2B6R049
- C2C9HR029
- C2C9HR026
- C1A1LR004
- C2C8R006
- INTO11E1
- C2B6LR002
- C3A5LR008
- C1A1R013B
- C2D6R002-1
- C1A2LR002
- C2A6R011
- C2E1R021
- C2C19R021
- C2D6R036
- C2C9R013
- C3A4BR053
- RED005B
- RED005
- BAC096A
- C3A4R053A
- C1A2R011C
- C1A2R010C
- C1A2R009A
- C46A1LR001A
- C17A1LR006
- C2C19BR020A
- C2C19BLR007A
- C2B6BLR002
- C3A7BR006
- C3A7R004
- C4F3BBR002
- C4F3BBLR002
- C4F3BR002
- C4F3BLR002
- C2C8BLR002
- C2C8BR006C
- C3A5BR006
- C3A5BR004B
- C2C8LR001
- INT047E3
- C3A5R004C
- C3A5BLR010
- C2C9*3BR001
- C4A11BR002
- BINT034E7
- C2B6BR049A
- C4F2BLR003B
- C4F2BLR003A
- INT034E2B
- C2C9BR013A
- C2C9BR013
- C2C9BHR029
- C2E1BR020B
- C3A4BLR010/A
- C2J2LR003B
- C2J2LR003A
- C2A13LR003/A
- INT034E7A
- INT030E18B
- C2C19LR008
- C2C19LR007/A
- C2D6*R004/B
- C2D6*2R004/A
- INT027E5C
- C4A11LR003/B
- C1B1*4LR002/A
- C1B1LR002/C
- C2C18LR003A
- C1B1*3LR002/A
- C2B6R050
- C2C9HR028B
- C1A1LR006
- C2C8R006C
- C2C8R005C
- C2C8R004/B
- C2B6LR002/A
- C3A5LR008/A
- C1A1R009D
- C2D6LR001-5B
- C1A2LR011/A
- C1A2LR010/A
- C1A2LR009/A
- C2A6R012A
- C3A4LR010/B
- C3A4LR007A
- C2E1R020
- C2E1R019/A
- C2C19R020B
- C2C19R020A
- C2C19R017D
- C2D6R038
- C2C9R012A
- C3A4BR053A
- BAC098B
- BAC097B
- BAC095B
- BAC095A
- C3A4R053
- C3A4R052B
- C3A4R052
- C1A2R011D
- C1A2R010G
- 1210411
- 0010183
- 0510017
- 1110064
- 0810396
- 0810395
- 0910241
- 1110040
- 0810451
- 0510064
- 0310131
- 0510053
- 1010154
- 1110446
- 1110008
- 1010153
- 1110457
- 1110186
- 0810064
- 0710330
- 0610395
- 1010320
- 1110469
- 0810074
- 1010187
- 0810014
- 0310239
- 0510273
- 0510141
- 1110390
- 1110172
- 0810025
- 0810497
- 1010108
- 1410291
- 1410269
- 0810436
- 1310026
- 1110521
- 1010123
- 0810364
- 1110135
- 0910313
- H706
- 611
- HC5-6
- HC3-41
- HC2-28
- HC1-10
- HC5-34
- HC4-24
- HC3-21
- H886
- H877
- H789
- HC2-18
- H683
- 0610370
- 1210079
- H694
- HC5-27
- HC3-5
- 0510093
- 1310201
- 0710094
- 0510021
- 0810316
- 0310051
- 0810037
- 0210292
- 1110092
- 1010188
- 1310232
- 1310234
- Z6000.S9
- Z6000.H15
- Z6000
- Z3000.S9
- Z3000
- Z2000.S9
- Z2000
- Z0610.ES9
- TMA.PED
- TMA.NORM
- TMA.NIDDM
- TMA.NASH
- TMA.NAS
- TMA.IDDM
- TMA.FIB
- TMA.ASH
- TMA.AS
- S1000.S9
- S1000.C
- S1000
- RPCH1000+
- RPCH1000
- R6000.S9
- R6000.H15+
- R6000.H15
- R6000.C
- R6000
- R3500.S9
- R3500.C
- R3500
- R3000.S9
- R3000.H15+
- R3000.H15
- R3000
- R2500.S9
- R2500.C
- R2500
- R2000.S9
- R2000.C
- R2000
- R1500.H15+
- R1500.H15
- R1500
- R1098
- R1093
- R1088
- R1083
- R1081.S9
- R1081
- R1078
- R1073
- R1063
- R1000.S9
- R1000.RS9
- R1000.RC
- R1000.R
- R1000.PS9
- R1000.PC
- R1000.P
- R1000.IS9(NP)
- R1000.IC(NP)
- R1000.IC
- R1000.I(NP)
- R1000.I
- R1000.HS
- R1000.H15+
- R1000.H15
- R1000.ES9
- R1000.E
- R1000
- R0610.LT
- PPCH2000+
- P2596
- P2595
- P2585
- P2583
- P2578
- P2573
- P2500.H15A
- P2500
- P2096
- P2095
- P2085
- P2083
- P2078
- P2073
- P2000.S9
- P2000.RC
- P2000.R
- P2000.PC
- P2000.P
- P2000.IS9(NP)
- P2000.IS9
- P2000.IC(NP)
- P2000.IC
- P2000.I(NP)
- P2000.I
- P2000.C
- P2000
- MPCH1000+
- MPCH1000
- M5000.S9
- M5000.C
- M5000
- M3000.S9
- M3000.C
- M3000
- M2000.C
- M1500.S9
- M1500.H15+
- M1500.H15
- M1500
- M1000.S9
- M1000.RS9
- M1000.R
- M1000.PS9
- M1000.PC
- M1000.P
- M1000.IS9(NP)
- M1000.IS9
- M1000.IC
- M1000.I(NP)
- M1000.I
- M1000.H15B+
- M1000.H15+
- M1000.H15
- M1000.ES9
- M1000.E
- M1000.C
- L1500.S9
- L1500.H15
- L1500.C
- L1500
- L1000.S9
- L1000.H15
- L1000.C
- L1000
- K8600
- K8400
- K8200
- K5200
- K5100
- K5000
- IFHP.96
- IFHP.48
- IFHP.24
- IFHP.12
- IFHP.06
- IFH15
- HU1A9.NA
- HU1A9.MA
- HU1A9.HA
- HU1A1.NA
- HU1A1.MA
- HU1A1.HA
- HPCH20-50
- HPCH10+
- HPCH10
- HPCH05+
- HPCH.UGT1A1.MA
- HPCH.UGT1A1.HA
- HPCH.OATP1B1.MA
- HPCH.OATP1B1.HA
- HPCH.3A5.NA
- HPCH.3A5.MA
- HPCH.3A5.HA
- HPCH.2D6.NA
- HPCH.2D6.MA
- HPCH.2D6.HA
- HPCH.2C9.MA
- HPCH.2C9.HA
- HPCH.2C8.MA
- HPCH.2C8.HA
- HPCH.2C19.NA
- HPCH.2C19.MA
- HPCH.2C19.HA
- HK1500.H15
- HK1000.H15
- HHNSH.S9
- HHNSH
- HHNML.S9
- HHNML
- HCP100.H15
- H3A5.NA
- H3A5.MA
- H3A5.HA
- H2D6.NA
- H2D6.MA
- H2D6.HA
- H2C9.MA
- H2C9.HA
- H2C19.NA
- H2C19.MA
- H2C19.HA
- H2640.S9
- H2640
- H2630.S9
- H2630
- H2620.S9
- H2620
- H2610-81
- H2610.S9
- H2610.C
- H2610
- H1500.S9
- H1500.H15T
- H1500.H15Q
- H1500.H15C+
- H1500.H15C
- H1500.H15B+
- H1500.H15B
- H1500.H15-3
- H1500.C
- H1500
- H1000.S9
- H1000.H15T
- H1000.H15C+
- H1000.H15C
- H1000.H15B+
- H1000.H15B
- H1000.H15-3
- H1000.C
- H1000
- H0640.S9
- H0640
- H0630.S9
- H0630
- H0620.S9
- H0620
- H0610-81
- H0610.S9
- H0610.RS9
- H0610.RC
- H0610.R
- H0610.PS9(S)
- H0610.PS9(NS)
- H0610.PC(S)
- H0610.PC(NS)
- H0610.P(S)
- H0610.P(NS)
- H0610.M
- H0610.L
- H0610.IS9(NP)
- H0610.IS9
- H0610.IC(NP)
- H0610.IC
- H0610.I(NP)
- H0610.I
- H0610.H
- H0610.ES9
- H0610.C
- H0610
- H0606.S9(AX)
- H0606.C(AX)
- H0604
- H0500
- G1000.S9
- G1000.C
- G1000
- D1500.S9
- D1500.C
- D1098
- D1095
- D1083
- D1078
- D1073
- D1063
- D1000.S9
- D1000.RS9
- D1000.RC
- D1000.R
- D1000.PS9
- D1000.PC
- D1000.P
- D1000.IS9(NP)
- D1000.IS9
- D1000.IC(NP)
- D1000.I(NP)
- D1000.I
- D1000.H15B+
- D1000.H15B
- D1000.H15+
- D1000
- CYP532
- CYP531-25
- CYP530-25
- CYP530-10
- CYP529-25
- CYP528
- CYP527-25
- CYP524-1000
- CYP524-100
- CYP523-25
- CYP523-100
- CYP521-25
- CYP521-10
- CYP519
- CYP517-25
- CYP517-10
- CYP514
- CYP513
- CYP511
- CYP509
- CYP508
- CYP507
- CYP506
- CYP504
- CYP503
- CYP502
- CYP501-5
- CYP501
- CYP500
- CYP457
- CYP456
- CYP454
- CYP453
- CYP452
- CYP451
- CYP430
- CYP402
- CYP401
- CYP400
- CYP366
- CYP365
- CYP364
- CYP363
- CYP362
- CYP361
- CYP360
- CYP335
- CYP334
- CYP333
- CYP332
- CYP331
- CYP330
- CYP308
- CYP307
- CYP306
- CYP305
- CYP304
- CYP303
- CYP302
- CYP301
- CYP300
- CYP208
- CYP205
- CYP204
- CYP203
- CYP202
- CYP201
- CYP200
- CYP156
- CYP155
- CYP153
- CYP152
- CYP151
- CYP150
- CYP121
- CYP120
- CYP107
- CYP106
- CYP105
- CYP103
- CYP102
- CYP101
- CYP100
- CYP099
- CYP072
- CYP068
- CYP067
- CYP066
- CYP065
- CYP063
- CYP062
- CYP061
- CYP060
- CYP059
- CYP058
- CYP057
- CYP056
- CYP055
- CYP054
- CYP053
- CYP052
- CYP051
- CYP050
- CYP049
- CYP048
- CYP047
- CYP045
- CYP044
- CYP043
- CYP042
- CYP041
- CYP040
- CYP039
- CYP037
- CYP036
- CYP035
- CYP034
- CYP033
- CYP032
- CYP031
- CYP030
- CYP029
- CYP028
- CYP027
- CYP026
- CYP025
- CYP024
- CYP023
- CYP022
- CYP021
- CYP020
- CYP019
- CYP018
- CYP017
- CYP016
- CYP015
- CYP014
- CYP013
- CYP012
- CYP011
- CYP009
- CYP008
- CYP007
- CYP006
- CYP005
- CYP004
- CYP003
- CYP002
- CYP001
- CYP/EZ068
- CYP/EZ067
- CYP/EZ065
- CYP/EZ064
- CYP/EZ063
- CYP/EZ062
- CYP/EZ061
- CYP/EZ060
- CYP/EZ059
- CYP/EZ058
- CYP/EZ057
- CYP/EZ056
- CYP/EZ055
- CYP/EZ052
- CYP/EZ049
- CYP/EZ048
- CYP/EZ047
- CYP/EZ046
- CYP/EZ045
- CYP/EZ044
- CYP/EZ043
- CYP/EZ042
- CYP/EZ041
- CYP/EZ040
- CYP/EZ039
- CYP/EZ038
- CYP/EZ037
- CYP/EZ036
- CYP/EZ035
- CYP/EZ034
- CYP/EZ033
- CYP/EZ032
- CYP/EZ031
- CYP/EZ030
- CYP/EZ028
- CYP/EZ027
- CYP/EZ026
- CYP/EZ025
- CYP/EZ024
- CYP/EZ023
- CYP/EZ022
- CYP/EZ021
- CYP/EZ020
- CYP/EZ019
- CYP/EZ018
- CYP/EZ017
- CYP/EZ016
- CYP/EZ015
- CYP/EZ014
- CYP/EZ013
- CYP/EZ012
- CYP/EZ011
- CYP/EZ010
- CYP/EZ009
- CYP/EZ008
- CYP/EZ007
- CYP/EZ006
- CYP/EZ005
- CYP/EZ003
- CYP/EZ002
- CYP/EZ001
- Clearance R6000.H15+ Lots
- Clearance R3500 Lots
- Clearance R3000.S9 Lots
- Clearance R3000.H15 Lots
- Clearance R3000 Lots
- Clearance R1500 Lots
- Clearance R1088 Lots
- Clearance R1081 Lots
- Clearance R1073 Lots
- Clearance R1000.RS9 Lots
- Clearance R1000.PS9 Lots
- Clearance R1000.P Lots
- Clearance R1000.H15+ Lots
- Clearance M3000.C Lots
- Clearance M3000 Lots
- Clearance M1500.S9 Lots
- Clearance M1500.H15 Lots
- Clearance M1000.S9 Lots
- Clearance L1000.H15 Lots
- Clearance H2610.C Lots
- Clearance H1500.H15T
- Clearance H1500.H15C
- Clearance H1500.H15B
- Clearance H1500.H15-3
- Clearance H1500.C Lots
- Clearance H1500 Lots
- Clearance H1000.H15T
- Clearance H1000.H15B
- Clearance H1000.H15-3
- Clearance H0610.RS9 Lots
- Clearance H0610.IS9(NP) Lots
- Clearance G1000 Lots
- Clearance D1000.S9 Lots
- Clearance D1000.RS9 Lots
- Clearance D1000.RC Lots
- Clearance D1000.PS9 Lots
- Clearance D1000.P Lots
- Clearance D1000.IS9(NP) Lots
- Clearance D1000.I(NP) Lots
People
- Chris Bohl
- Andrew G. Taylor
- Kusum Parikh
- Steve McGreal
- Pratik Home
- Pallavi Limaye
- Sara McKinney
- Rebecca Pilcher-Maggert
- Julie Scheinkoenig
- Lois Haupt
- Rebecca Campbell
- Seema Muranjan
- Aaron Hilgedick
- Jennifer Horkman
- Immaculate Amunom
- Rebekah Snyder
- Stephanie Helmstetter
- Michelle McBride
- Rachel Murphy
- Larry Wienkers, Ph.D.
- Ajay Madan, Ph.D.
- Jane Kenny, Ph.D.
- Griff Humphreys, Ph.D.
- Zell Woodworth
- Andrea Wolff
- Etsuko Usuki
- Maciej Czerwinski
- Jennifer Osborne
- Brian Ogilvie
- Joanna Barbara
News
- May 1st Transition of XenoTech.com Products and Services to BioIVT.com
- XenoTech Joins BioIVT: Expands Biospecimens Portfolio and Research Services
- New PALSAR Method Now Available for Bioanalysis of Oligonucleotides and Other Intermediate Molecules
- New Efficiencies Lower Study Timelines While Maintaining Quality Standards
- Increased Access to OATP2B1 Drug Transporter Studies
- Reduction of Energy a Priority at XenoTech
- New Cysteine Trapping Study Now Available for More Efficient & Effective Early Phase Drug-Induced Liver Injury (DILI) Evaluation
- XenoTech expands access to Microsomal Protein Binding service for DMPK profile development and DDI assessment of new drugs
- XenoTech expands access to Red Blood Cell Partitioning service for improved pharmacokinetics assessments
- Introducing New CryostaX Individual Donor Human Hepatocytes
- ADME & DDI Contract Research Organization Announces New Website Launch
- XenoTech Receives New US Patent for a Method to Evaluate Xenobiotics as Immune-Modulators of Drug Transport and Metabolism in Hepatocytes
- XenoTech Expands Access to Top-Tier DDI Expertise & Consultancy
- New Head of KC-Based Drug Development CRO Poised for Further Growth and Expansion
- XenoTech Announces Expanded Consulting Opportunities Available to Clients
- XenoTech Announces Enhanced Synergy in ADME Testing Services
- XenoTech Celebrates 25th Anniversary
- XenoTech Achieves Record Revenue and Employment Numbers
- XenoTech Announces Creation of Scientific Advisory Board (SAB)
- XenoTech Adds Monkey, Rodent Hepatocytes to Patented CryostaX Product Line
- XenoTech Receives New US Patent for Evaluating Xenobiotic Drug Metabolism in Hepatocytes
- XenoTech Adds Fatty Liver Disease Tissue Arrays, Microsome Pool to Research Biobank
- XenoTech Hiring and Growing to Meet Customer Demand
- New Enhanced AO & XO Activity Test Systems Available, Major CYP Activity Not Significantly Impacted
- XenoTech Awarded Cryopreservation Patent, Achieves Numerous Hepatocyte Enhancements
- XenoTech Adds New Dermal Subcellular Fraction Test Systems
- XenoTech Introduces Lysosomal Test Systems for Biopharmaceutical Development
- XenoTech Introduces New Research BioBank
- XenoTech Provides Genotyped Hepatocytes for Polymorphic Enzyme Drug Metabolism Studies
- XenoTech Accepting Global Scientific Achievement Award Nominations for 2015
- XenoTech Provides Pooled Human Liver Homogenate for Evaluation of Drug Metabolizing Enzymes and Proteins
- XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014
- Case Study: XenoTech Ensures Quality
- XenoTech Scientists Solve Long-Standing Mystery in Drug Metabolism
- XenoTech Teams Up with JCRB to Provide Access to Over 1,100 Cell Lines in North America
- XenoTech Receives US Patent for Its Novel Approach to Evaluate Therapeutic Proteins as Immune Modulators of Drug Metabolism
- Joint XenoTech / Provectus Article Published by Xenobiotica
- For Additional News
Events
- RI-ADE ADME 101: Non-clinical pharmacokinetics studies using radio-labeled compounds
- Dual-Hybridization PALSAR (Probe Alternation Link Self-Assembly Reaction) Technology Introduction
- Webinar: Design Intricacies and Decision-Making Strategy for DDI Studies
- 2022 ISSX/MDO Meeting
- Webinar: New 2022 Draft ICH Drug Interaction Studies Global Guideline
- Webinar: Role of Sulfotransferases in Drug Metabolism and Potential for Drug-Drug Interactions
- 2022 SOT Annual Meeting and ToxExpo
- Webinar: Bridging In Vitro Data to Clinical Outcomes with MetID
- 2021 Holiday Wishes
- Webinar: Role of UDP-Glucuronosyltransferases in Drug Metabolism and Drug-Drug Interactions
- Webinar: Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism: Important Considerations for In Vitro Assessment
- Webinar: Addressing Unique Challenges with Custom In Vitro Test Systems
- Webinar: The Role of In Vitro Assays in Selecting the Right Species for Your Small Molecule Program
- Webinar: Red Blood Cell Partitioning Studies to Improve Accuracy in Pharmacokinetics (PK) Calculations
- March 31st DDI Guidance Webinar with Access to a Panel of Drug Metabolism & DDI Experts
- Webinar: An Overview of Non CYP-Mediated Metabolism Pathways and In Vitro Evaluation Strategies
- 2C or Not 2C: CYP2C Induction Studies for Successful Preclinical Risk Assessment
- Presentation at 2020 ACT Meeting
- Poster at 2020 AAPS PharmSci 360 Meeting
- DMDG Webinar - Comparison Between the Final FDA, EMA, and PMDA In Vitro DDI Guidance Documents: Are We Finally Harmonized?
- Webinar - Suicide by Binding: Putting Time-Dependent Inhibition of CYP Enzymes into Perspective
- 2019 SOT Meeting & ToxExpo
- XenoTalks™ Seminar Series: The Importance of ADME and DDI in Drug Development
- Webinar: In Vitro Inhibition Studies - Elements of Design and Important Considerations in Data Analysis
- 2020 SOT Online Meeting
- 2019 Holiday Wishes
- 2019 EBF Open Symposium
- 2019 ACT Meeting
- 2019 AAPS PharmSci 360
- GMP Annual Symposium 2019
- PBSS Vancouver Workshop on Preclinical Development
- EUROTOX 2019
- Webinar: Transporters of Emerging Importance in Drug Development - Beyond the Guidance Documents
- Webinar: In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis
- Boston Society Transporter Workshop
- 2018 Holiday Wishes
- 2018 Liver Meeting
- ACT 2018
- PBSS San Francisco Workshop on Drug-Drug Interactions
- DMDG & Swedish Academy of Pharmaceutical Sciences Meeting
- Peptide ADME Discussion Group Workshop
- Webinar: Improving hepatocyte pooling, activity and lab efficiency
- Webinar: Patient-Derived Tumor Organoids for Personalized Medicine & Targeted Drug Discovery
- 2017 Holiday Wishes
- 2015 Holiday Wishes
- For Additional Webinars
Resources
- RI-ADE ADME 101: Non-clinical pharmacokinetics studies using radio-labeled compounds
- Dual-Hybridization PALSAR (Probe Alternation Link Self-Assembly Reaction) Technology Introduction
- Design Intricacies and Decision-Making Strategy for Drug-Drug Interaction Studies
- Establishment of PALSAR method for quantification of human cells in mouse kidney
- Highlights of the In Vitro Sections of the Draft ICH Drug Interaction Studies Guideline and Comparison with Current Guidance
- Highly selective and sensitive hybridization-based assay for quantification of ASOs drug using signal amplification method
- A Novel ADA Screening Assay for Immunogenicity Testing of Oligonucleotide Drug Using PALSAR Technology
- Investigation of the PPB method for oligonucleotide drugs by using the PALSAR
- 2022 FDA Draft Guidance for Industry "Clinical Pharmacology Considerations for the Development of Oligonucleotide Therapeutics"
- In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions
- 2022 ICH M12 Draft Guideline for Drug Interaction Studies
- In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions
- Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary
- Role of Sulfotransferases (SULTs) in Drug Metabolism and Potential for Drug-Drug Interactions
- A Guide to In Vitro CYP Inhibition Studies: Elements of Study Design and Important Considerations in Data Analysis
- Webinar: Bridging In Vitro Data to Clinical Outcomes with MetID
- ADME 101: Microsomal Protein Binding of Drugs
- Reactive Metabolite Detection Studies: Cysteine Trapping
- In Vitro Strategies for Evaluating Non-CYP Metabolism Pathways
- Role of UDP-Glucuronosyltransferases (UGTs) in Drug Metabolism and Drug-Drug Interactions
- Establishment of the PPB method for antisense oligonucleotides (ASOs) by using the PALSAR method
- SAFETY FIRST: Assessing drugs early can preclude regulatory and health issues
- Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism: Important Considerations for In Vitro Assessment
- Addressing Unique Challenges with Custom In Vitro Test Systems
- The Role of In Vitro Assays in Selecting the Right Species for Your Small Molecule Program
- Red Blood Cell Partitioning Studies to Improve Accuracy in Pharmacokinetics (PK) Calculations
- An Overview of Non CYP-Mediated Metabolism Pathways and In Vitro Evaluation Strategies
- 2C or Not 2C: CYP2C Induction Studies for Successful Preclinical Risk Assessment
- In Vitro Cholestatic DILI & Mitochondrial Toxicity Studies to Assess Hepatotoxicity
- ADME 101: Drug Metabolism Studies - Metabolic Stability
- Effects of Monocyte Chemoattractant Protein-1, Macrophage Inflammatory Protein-1α and Interferon-α2a on P450 Enzymes in Human Hepatocytes in Vitro
- ADME 101: Model-Based Approaches to DDI Risk Prediction - Navigating the Transition from In Vitro Data to In Silico Modeling
- An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
- Suicide by Binding: Putting Time-Dependent Inhibition of CYP Enzymes into Perspective
- 2020 FDA Draft Guidance, "Drug-Drug Interaction Assessment for Therapeutic Proteins Guidance for Industry"
- ADME 101: Biobank Fatty Liver Disease Tissues and Their Exploration in Microarrays
- ADME 101: Enzyme Induction Studies
- ADME 101: Which Hepatocyte Test System Should I Use?
- In Vitro Study Timing
- ADME 101
- Toxicity evaluation by high content analysis of 3D cultured primary human hepatocytes
- ADME 101: Efflux and Uptake Drug Transporters
- ADME 101: Reaction Phenotyping Studies in Drug Metabolism
- ADME 101: Lysosomal Trapping
- ADME 101: Guide to Subcellular Fractions and When to Use Which Test System
- In Vitro Inhibition Studies: Elements of Design and Important Considerations in Data Analysis
- Scientific Posters
- Comparison Between the Final US FDA, Japan PMDA, and EMA In Vitro DDI Guidance Documents: Are We Finally Harmonized?
- In Vitro ADME & Drug-Drug Interaction Considerations for Toxicologists
- ADME 101: Considerations & Calculations When Sending In Vitro Test Articles
- The Basics of In Vitro Xenobiotic Metabolism and Drug-Drug Interaction Investigations: Applicability to All Xenobiotics
- Safety Testing of Drug Metabolites ("MIST")
- Comparison Between the Final US FDA, Japan PMDA and EMA In Vitro DDI Guidance
- ADME 101 FAQ: Tips & Tricks for Working with Plateable Hepatocytes
- ADME 101: Metabolite ID & Characterization Studies FAQ
- 2020 FDA Final Guidance, "In Vitro Drug Interaction Studies-- Cytochrome P450 Enzyme- and Transporter-Mediated Drug Interactions"
- The evaluation of induction and inhibition potency of various drugs on CYP3A4 and OATP1B1/1B3
- Effects of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and interferon-α2a on P450 enzymes in human hepatocytes in vitro
- Drug Metabolism Related Safety Considerations in Drug Development
- ADME 101: DMPK and ADME in Drug Development
- CYP1A2 enzyme activity and protein abundance in normal and diseased pediatric livers
- CYP1A2 enzyme localization in normal and diseased pediatric livers
- Human mAb stability and cytotoxicity in rat hepatocytes with a surrogate peptide approach
- Dexamethasone reduces airway epithelial Cl− secretion by rapid non-genomic inhibition of KCNQ1, KCNN
- Human monoclonal antibody stability in rat cell cultures using surrogate peptide LC-MS/MS
- An assessment of in vitro inhibition of CYPs, UGTs and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides
- Transporters of Emerging Importance in Drug Development: Beyond the Guidance Documents
- In Vitro Induction Studies: Elements of Design and Important Considerations in Data Analysis
- Patterns of hyaluronan deposition in normal and diseased pediatric livers
- In Vitro Evaluation of Immunomodulating Drugs as Perpetrators of Drug Interactions
- 2019 PMDA Guideline (English Translation), "Guideline on drug interaction for drug development and appropriate provision of information"
- Understanding P-gp & BCRP Inhibition Assay Design & Outcomes
- 2017 FDA Guidance: Many In Vitro DDI Evaluations Should Precede FIH Studies
- Chapter 6: Biotransformation of Xenobiotics
- Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis
- Cytokine-mediated suppression of CYP enzymes by a toll-like receptor 9 agonist in hepatocytes
- Ultrasensitive quantitation assay of oligonucleotide therapeutics based on the PALSAR method
- Inhibitory effect of typical CYP inhibitors under long term incubation in human liver microsomes
- Strategies to improve the predictions accuracy of hepatic intrinsic clearance of three antidiabetic drugs: application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OAT1B1-mediated hepatic uptake
- CryostaX Pellets: Improving hepatocyte pooling, activity and lab efficiency
- Challenges and solutions in today's in vitro transporter research
- Microsomal cytochrome P450 (CYP) enzyme activities in nonalcoholic steatohepatitis (NASH) livers
- Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies
- Challenges & Solutions In Today’s In Vitro Transporter Research Landscape
- Patient-Derived Tumor Organoids for Personalized Medicine & Targeted Drug Discovery
- An assessment of the in vitro inhibition of cytochrome P450 enzymes (CYP), UDP-glucuronsyltransferases (UGT) and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides
- Direct and cytokine‐mediated effects of albumin‐fused growth hormone, TV‐1106, on CYP enzyme expression in human hepatocytes in vitro
- Direct and cytokine‐mediated effects of albumin‐fused growth hormone on CYP expression
- In Vitro Products & Reagents Technology Guide
- Comparison of two hepatic uptake assay methods
- Evaluation of interspecies metabolic activities for non-CYP enzymes
- 2017 FDA Draft Guidance, "In Vitro Metabolism- and Transporter- Mediated Drug-Drug Interaction Studies"
- Further exploration into the DDI between Gemfibrozil & Repaglinide in rats: Uptake Transporters
- In Vitro Studies with Two Human Organic Anion Transporters: OAT2 & OAT7
- Effects of organ preservation solution on aldehyde oxidase and xanthine oxidase activity in pooled human liver S9
- DDI Guidance Recommendations on Down-Regulation, CYP2C Induction and CYP2B6 Control
- Characteristics of Fatty Liver Disease (FLD) Tissue Infographic
- Hepatocytes as the preferred test system to evaluate oligonucleotide-CYP Interactions in vitro
- Drug Metabolizing Enzymes and Transporters in NASH
- Research collection of variants of normal and fatty liver disease in human livers
- Evaluation of the CYP metabolic activities in the presence of albumin in human liver microsomes
- Evaluation method for mitochondrial toxicity using Crabtree effect
- Adverse drug interaction risks in genetically-defined subpopulations
- In Vitro Evaluation of Ketoconazole and its Alternatives as Non-CYP Inhibitors
- Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure
- Evaluation of Ketoconazole and its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters
- Hepatocyte Plating Demo With XenoTech's New Optimized Media
- Hepatocyte Thawing Demo With XenoTech's New Optimized Media
- Tritosomes and Lysosomes for Characterization of Biologic Drugs
- Automated High Content Drug Transport Screening with Transwell Plates for Drug Discovery
- In vitro characterization of human liver lysosomes isolated from fresh tissue
- Efficient use of chimeric mice with humanized livers for drug development support
- Evaluation of Chemical Inhibitors for UDP-glucuronosyltransferase UGT Reaction Phenotyping Assays
- Comparison of Ki and IC50 Values for Prototypical Inhibitors of ABC Transporters
- Comparative Investigation of Benzoapyrene, Procaine and Nevirapine Metabolism in Human Hepatocytes
- UGT Inhibition Studies in the Presence or Absence of Alamethicin
- The Impact of Various Solvents and Solvent Concentrations on In Vitro Enzyme Induction Assessment
- The reliability of estimating Ki values for direct, reversible inhibition of cytochrome P450 enzymes from corresponding IC50 values: A retrospective analysis of 343 experiments
- Further Characterization of the Metabolism of Desloratadine and its Cytochrome P450 and UDP-Glucuronosyltransferase (UGT) Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor
- Effects of Albumin-Fused Human Growth Hormone TV-1106 on CYP Enzyme Expression in Human Hepatocytes
- In Vitro Assessment of the Drug-Drug Interaction of Rasagiline and Its Metabolite Aminoindan
- Evaluation of BSEP Inhibitors Using B-CLEAR® Human Hepatocytes to Predict Inhibition and Cholestasis
- Comparison of Ki and IC50 Values for Prototypical Inhibitors of ABC Transporters P-gp and BCRP
- Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents
- Automated Plasma Protein Binding Using Rapid Equilibrium Dialysis
- Rapid mRNA Induction Screen
- A long-standing mystery solved: The formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UGT2B10 is an obligatory requirement
- Effects of Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates
- Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in Pooled Human Liver Microsomes and Hepatocytes
- Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters
- In Vitro System-Dependent Inhibition of CYPs, UGTs, and Drug Transporters by Oligonucleotides
- The Impact of Incomplete Dose-Response Curves on EC50 and Emax Determinations in Enzyme Induction
- Exploring the Drug-Drug Interaction Between Gemfibrozil and Repaglinide in Rats
- The Use of Pooled Plated Cryopreserved Human Hepatocytes for the Determination of Metabolic Clearance, CYP Induction, and Uptake Transporter Studies
- Anti-CD28 Monoclonal Antibody-stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6 and CYP3A4 in Human Hepatocytes In Vitro
- Drugs as Victims and Perpetrators and the Pharmacokinetic Concept of Maximum Exposure
- Induction of UDP-Glucuronosyltransferases in Cultures of Fresh and Immortalized Human Hepatocytes
- In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential
- Comparison of XenoTech Hepatocytes to HepaRG® Cell Line
- High content automated metabolic stability and CYP inhibition cocktail screening assays for early drug development
- 2012 EMA Final Agency Guideline, "Guideline on the Investigation of Drug Interactions"
- Human liver S9 fractions stored at -70°C maintain high phase I and phase II enzymatic activities over multiple freeze/thaw cycles and for at least 10 years
- High-resolution mass spectrometry for rapid metabolite characterization and reaction phenotyping: a case study with repaglinide
- Midazolam clearance in human hepatocytes is restricted compared with human liver microsomes but not by cell permeability or cofactor availability
- Substrate-Specific Inactivation of CYP3A by the HIV Protease Inhibitors Ritonavir, Saquinavir and Amprenavir
- Endotoxin up-regulates the proinflammatory cytokines TNF-α and IL-6 in freshly-isolated human Kupffer cells
- Time-course of Cytochrome P450 (CYP450) induction in cultured human hepatocytes
- Comparing Ki and IC50 Values
- Test system-dependent clearance of CYP2D6 and CYP3A4/5 substrates
- Selection of human liver S9 and cytosol fractions for evaluating clearance by aldehyde oxidase (AO)
- BCRP Transport Inhibition
- Aldehyde Oxidase: Why In Vitro Absolute Activity Doesn't Matter
- Navigating the Transporter Wave of 2013: A Review of the Seven Recent ITC Publications on Drug Transporters
- Exploring the Utility of High-Resolution MS with Post-Acquisition Data Mining for Simultaneous Exogenous and Endogenous Metabolite Profiling
- Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate
- Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 cells)
- Exploring the Mechanism of CYP3A4 Inactivation by Lapatinib Through In Vitro Metabolite Char.
- Uptake and Efflux Transporters
- Inhibitors of Uptake Transporters
- Application of Hepatocytes for In Vitro Uptake Assays
- High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs During In Vitro Metabolite Profiling
- Catechol and aldehyde moieties of 3,4-dihydroxyphenylacetaldehyde contribute to tyrosine hydroxylase inhibition and neurotoxicity
- Activator Protein-1 Regulation of Murine Aldehyde Dehydrogenase 1a1
- 2012 FDA Draft Guidance, "Drug Interaction Studies — Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations"
- Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: A case study example with the prodrug ceftobiprole medocaril
- Esomeprazole, omeprazole sulfone, 5-O-desmethyl omeprazole and 5-hydroxylansoprazole are in vitro metabolism-dependent inhibitors of CYP2C19
- Can Ki values for direct inhibition of CYP enzymes be reliably estimated from IC50 values?
- A robust method to identify compounds that undergo intracellular lysosomal sequestration
- An in vitro test system to evaluate drug-drug interactions with biologics
- Evaluation of dilution, dialysis and ultracentrifugation methods to assess the reversibility of metabolism-dependent inhibitors (MDIs) of cytochrome P450 (CYP) enzymes
- Temporal changes in CYP3A4 mRNA and activity following treatment of cultured human hepatocytes with interleukin-6 (IL-6): Implications for study design and endpoint selection
- Evaluating the potential for lysosomal trapping in immortalized human hepatocytes (Fa2N-4 cells)
- Evaluating the potential for lysosomal trapping in immortalized human hepatocytes (Fa2N-4 cells)
- An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes
- The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel
- Comprehensive Quantitative and Qualitative Liquid Chromatography–Radioisotope–Mass Spectrometry Analysis for Safety Testing of Tolbutamide Metabolites Without Standard Samples
- The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes
- Accurate mass spectrometry elucidates a misleading metabonate formed from amine-containing drugs in reactive metabolite screening assays
- In vitro inhibition and induction of human liver cytochrome P450 enzymes by NTBC and its metabolism in human liver microsomes
- In situ evaluation of CYP1A2, CYP2B6 and CYP3A4/5 induction in cultured human hepatocytes with a cocktail of probe substrates: A comparison of percent positive control values
- Identification of a novel carbamoyl glucuronide as a metabolism-dependent inhibitior of CYP2C8
- The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes
- Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to Underestimation of the Shifted IC50 Value
- 2010 EMA Draft Guideline, "Guideline on the Investigation of Drug Interactions"
- M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals
- Induction of Liver and Intestinal Cytochrome P450 (CYP) Enzymes in Male and Female Cynomolgus Monkey
- Effects of Gender, Age and Ethnicity on Human Cytochrome P450 Activity
- Microsomes and S9 Prepared from Renal Tissue Yield High CYP, FMO and UGT Activities that are Stable…
- Liver CYP Enzyme Activities in Selected Species
- Cytochrome P450 3A4 and 1A2 Induction in Immortalized and Primary Cultures of Human Hepatocytes
- Microsomes Prepared from Eluted Enterocytes Yield High Cytochrome P450 and UGT Activities that are…
- The Use of Immortalized Hepatocytes in Induction Studies
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