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Drug Transporters

Drug transport studies use regulatory guidance-compliant test systems to investigate a compound’s potential to operate as a substrate or inhibitor of known uptake (SLC) and efflux (ABC) transporters, precipitating a potential drug-drug interaction. For more information about these services, visit our Drug Transport contract service page.

 

Webinars

ADME 101: Efflux and Uptake Drug Transporters

Presented by Andrew Taylor, Ph.D., Services Technical Support Manager Drug transport can be thought of as the AD&E in ADME, as transporters are responsible for absorption, distribution,...
Webinars

ADME 101: Lysosomal Trapping

Presenter:  Andrew Taylor, Ph.D., Services Technical Support Manager This ADME 101 video discusses how compounds can become trapped by lysosomes, which can lead to high...
Blog

ADME and Drug-Drug Interactions for the Toxicologist

Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...

Blog

In Vitro Evaluation of Drug-Drug Interaction (DDI) Potential

In its most recent in vitro drug interaction guidance update, the US Food and Drug Administration (FDA) emphasized harmony with the...

Blog

Four ways to optimize preclinical in vitro data to mitigate risk of late-stage clinical failure

1. Collect high-quality data to make informed, confident go/no go decisions for moving your drug candidate forward If you need...

Blog

How can in vitro and in vivo studies help me understand my drug’s clearance?

Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...

Blog

Timing of In Vitro Studies: Early, Thorough ADME for Your Compound’s Success

Beyond the need for evidence that a drug works, Food and Drug Administration (FDA) and other regulatory bodies around the...

Scientific Posters

The evaluation of induction and inhibition potency of various drugs on CYP3A4 and OATP1B1/1B3

Presented at the 34th JSSX Annual Meeting in Tsukuba, Japan Authors Ryota Takeuchi, Rena Kusano, Tomoko Sasai, Takami Sarashina, Ryo Fujino, Kenta Hashizume  Drug Development...
Blog

What In Vitro Metabolism and DDI Studies Do I Actually Need?

Though there is no ‘roadmap’ spelling out required studies to achieve regulatory approval for clinical entry, a drug candidate’s metabolism...

Blog

Can CYP3A4 Induction Predict P-glycoprotein Induction in DDI Studies?

Generally, a drug’s effects on enzyme and transporter activity are examined independently in a drug development program, but what if...

Blog

Reduced Pricing for In Vitro Transporter Studies

We’re pleased to announce that our scientists’ ongoing dedication to enhancing our processes and discovering new efficiencies without sacrificing quality...

White Papers

Dexamethasone reduces airway epithelial Cl− secretion by rapid non-genomic inhibition of KCNQ1, KCNN

Darina Hynes (SEKISUI XenoTech EU Business Development Manager), Brian J.Harvey Basolateral membrane K+ channels play a key role in basal and agonist stimulated Cl− transport across airway epithelial cells...
Scientific Posters

An assessment of in vitro inhibition of CYPs, UGTs and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides

Presented at the 2019 Marbach Castle Drug-Drug Interaction Workshop in Germany by Dr. Brian W. Ogilvie. Authors The poster presented information based on the publication:...
Webinars

Transporters of Emerging Importance in Drug Development: Beyond the Guidance Documents

Presenter: Brian Ogilvie, Ph.D., SEKISUI XenoTech Vice President of Scientific Consulting Synopsis: In October, 2017, the US FDA revised and split its 2012 draft guidance for...
Blog

Important Considerations for the Conduct of In Vitro Drug Transporter Assays

Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...

Webinars

Understanding P-gp & BCRP Inhibition Assay Design & Outcomes

Presenter: Andrea Wolff, SEKISUI XenoTech Director of Services Logistics Synopsis: In vitro drug transporter inhibition studies are recognized for their importance due to the major role transporters...
Blog

Coverage from the October 2018 PBSS DDI Workshop

The Pharmaceutical and BioScience Society (PBSS) hosted the workshop “Drug-Drug Interactions: Update on Risk Assessment, Clinical Evaluation and Regulatory Requirements” on October...

Publications

Strategies to improve the predictions accuracy of hepatic intrinsic clearance of three antidiabetic drugs: application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OAT1B1-mediated hepatic uptake

Ryo Fujino, Kenta Hashizume, Shinsuke Aoyama, Kazuya Maeda, Kiyomi Ito, Kota Toshimoto, Wooin Lee, Shin-ichi Ninomiya, Yuichi Sugiyama The antidiabetic drugs glibenclamide, repaglinide, and nateglinide...
Blog

New Recommendation: Evaluate NMEs for OCT1 Transporter-Mediated DDI Potential

Brian Ogilvie, Ph.D., Vice President of Scientific Consulting at SEKISUI XenoTech, presented a case study on the importance of the hepatic...

Publications

Challenges and solutions in today’s in vitro transporter research

Dr. Joanna Barbara In vitro drug transport assays are performed throughout drug development and range from simple permeability screens to kinetic assessments in complex assay formats. Sometimes interpreting...
Blog

Challenges & Solutions in Today’s In Vitro Transporter Research

Transporters are membrane-bound proteins that govern the passage of drugs into and out of cells. These gatekeeper proteins can be...

Webinars

Challenges & Solutions In Today’s In Vitro Transporter Research Landscape

Presented by: Joanna Barbara, Ph.D., SEKISUI XenoTech Vice President of Scientific Operations Originally Aired: 20 June 2018 Key concepts discussed in this webinar will include:...
Blog

AAPS-FDA Drug Transporters

The American Association of Pharmaceutical Scientists (AAPS) and U.S. Food and Drug Administration (FDA) co-sponsored the workshop “Drug Transporters in ADME:...

Publications

An assessment of the in vitro inhibition of cytochrome P450 enzymes (CYP), UDP-glucuronsyltransferases (UGT) and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides

Faraz Kazmi, Phyllis Yerino, Chase McCoy, Andrew Parkinson, David B Buckley and Brian W Ogilvie Oligonucleotides represent an expanding class of pharmacotherapeutics in development for...
Blog

SEKISUI XenoTech Adds US and Japanese Support for MATE1 and MATE2-K Drug Transporter Studies

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...

Scientific Posters

Comparison of two hepatic uptake assay methods

Authors Akito Takahashi, Ryota Takeuchi, Ryo Fujino, Kenta Hashizume, Shin-ichi Ninomiya Drug Development Solutions Center, Drug Development Solutions Division, Sekisui Medical Co., Ltd. 2117 Muramatsu,...
Blog

Further Research on the Drug-Drug Interaction Between Gemfibrozil and Repaglinide Presented

The clinically-relevant drug-drug interaction (DDI) between the dyslipidemia drug gemfibrozil and the antidiabetic repaglinide is well-documented throughout the literature. In...

Scientific Posters

Further exploration into the DDI between Gemfibrozil & Repaglinide in rats: Uptake Transporters

Presented at ISSX 2017 Annula Meeting Authors Chase I. McCoy, Forrest A. Stanley, Chandra Kollu, Seema Muranjan, Krystal M. Green and Joanna E. Barbara Abstract...
Publications

In Vitro Studies with Two Human Organic Anion Transporters: OAT2 & OAT7

Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues...
Blog

URI Drug Transporters Workshop Presentations

The University of Rhode Island College of Pharmacy’s 5th Annual Transporters in Drug Discovery and Development: Driving Knowledge from Laboratory...

Blog

SEKISUI XenoTech Adds New Drug Transporters to Portfolio

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...

Blog

XenoTech Scientists Publish Paper, Present Research Evaluating Ketoconazole and its Alternative Clinical CYP3A4-5 Inhibitors as Inhibitors of Drug Transporters

SEKISUI XenoTech scientists published a paper in Drug Metabolism and Disposition evaluating Ketoconazole and its alternative clinical CYP3A4-5 inhibitors as inhibitors of drug...

Publications

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

The world’s oceans are a global reservoir of persistent organic pollutants to whichHumans and other animals are exposed. Although it is well known that these...
Webinars

Evaluation of Ketoconazole and its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters

Presented by: Lydia Vermeer, Ph.D., Senior Scientist, Drug Transport Ketoconazole is an orally available, synthetic, broad spectrum, antifungal agent. Approved in 1982 by the FDA...
Scientific Posters

Automated High Content Drug Transport Screening with Transwell Plates for Drug Discovery

The purpose of this study was to develop a method to use bidirectional intestinal permeability and drug transport to identify substrates and inhibitors of MDR1...
Scientific Posters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Human ABC Transporters P-gp

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Human ABC Transporters P-gp and BCRP in Membrane Vesicles P-gp (ABCB1/MDR1) and BCRP (ABCG2) are...
Scientific Posters

Accumulation of Taurocholic Acid in Hepatocytes

Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents Drug induced liver injury (DILI) has led to...
Scientific Posters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters We previously reported on the similarities and differences in Ki and IC50 values for various inhibitors...
Scientific Posters

Exploring the Drug-Drug Interaction Between Gemfibrozil and Repaglinide in Rats

Exploring the Drug-Drug Interaction Between Gemfibrozil and Repaglinide in Rats: Metabolism and Transport A clinically-relevant drug-drug interaction (DDI) between the dyslipidemia drug gemfibrozil and the antidiabetic...
Publications

Drugs as Victims and Perpetrators and the Pharmacokinetic Concept of Maximum Exposure

Brian W. Ogilvie, Andrew Parkinson This article describes the dramatic but predictable impact of two perpetrators on the disposition of a victim drug. For a...
Publications

2012 XenoTech Products & Services Catalog

The 2012 Products & Services Catalog was developed to provide an overview of our entire portfolio of capabilities, with a heavy emphasis on the services...
Scientific Posters

ISSX 2013 – Comparing Ki and IC50 Values

Comparison of Ki and IC50 values for prototypical and clinically-relevant probe substrates of the hepatic transporters OATP1B1 and OATP1B3 Organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1,...
Scientific Posters

ISSX 2013 – BCRP Transport Inhibition

System-dependent inhibition of BCRP transport by high- and low-permeable compounds in bi-directional MDCKII cells and membrane vesicles Breast cancer resistance protein (BCRP, ABCG2) is an...
Blog

Navigating the Transporter Wave of 2013

The International Transporter Consortium (ITC) issued 7 papers in the July 2013 issue of Clinical Pharmacology & Therapeutics. These 7...

Webinars

Navigating the Transporter Wave of 2013: A Review of the Seven Recent ITC Publications on Drug Transporters

Presented by: Greg Loewen, Amanda Hays and Andrea Wolff Seven papers were published by the International Transporter Consortium (ITC) in the July 2013 issue of Clinical...
Scientific Posters

AAPS Transporter 2013 – Uptake and Efflux Transporters

Comparison of IC50 Values for Prototypical and Clinically-Relevant Probe Substrates and Inhibitors of Selected Uptake and Efflux Transporters The EMEA Guideline on the Investigation of...
Scientific Posters

AAPS Transporter 2013 – Inhibitors of Uptake Transporters

Comparison of Ki and IC50 Values for Prototypical Inhibitors of Uptake Transporters Ki values were determined for prototypical inhibitors of uptake transporters with an experimental design incorporating...
Webinars

Application of Hepatocytes for In Vitro Uptake Assays

Presented by: David Buckley, Ph.D. – CSO This webinar provides a basic review of concepts applicable to a structure-based approach for the evaluation of hepatic...

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