Rat Intestine Subcellular Fractions

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Intestines play a significant role in first-pass metabolism of orally ingested xenobiotics. Consequences of intestinal biotransformation include toxification by bioactivation and detoxification by aiding in excretion. Intestines contain high concentrations of CYP and UGT metabolic enzymes, which are extracted from mature enterocytes of the villus tips.

Sekisui XenoTech’s rat intestinal subcellular fractions are processed in a way which yields the highest activity levels on the market, and includes the preparation of matching S9 and microsomes from Sprague-Dawley rats. These subcellular fractions are most commonly used for in vitro ADME studies.

For high esterase activity, choose Sekisui XenoTech's PMSF-free intestine subcellular fractions.
PMSF* is a serine protease inhibitor that inactivates trypsin and chymotrypsin found within the small intestine, but can also inhibit esterase activity in intestine subcellular fractions and interfere with your esterase assays. Our proven preparation method is essentially the same, without the addition of PMSF. Learn more here.

*PMSF (Phenylmethylsulfonylflouride)

If you require subcellular fractions not included in our standard product offering, custom products can be ordered to meet the needs of any study.

Features and Benefits:
  • Large donor pools minimize lot-to-lot variation
  • Large lots ensure long-term product availability
  • Matching S9 and microsome donor pools
  • Market-leading enzyme activity levels
  • Market-leading characterization performed using LC-MS/MS methods

Intestinal Diagram

Sekisui XenoTech only uses mature villus tips in the preparation of intestinal subcellular fractions. Other parts of the intestine, including the submucosa, muscularis and serosa, yield low microsome quantities and are discarded in order to ensure the highest quality intestinal subcellular fractions on the market.
Related Products:
Contact a Product Specialist for more information on Sekisui XenoTech’s subcellular fraction product offerings.
  Buy cell and tissue based products
Product Description Volume Protein Concentration
R1000.I Male IGS SD Rat Intestinal Microsomes - 10mg/mL - Pooled 0.15mL 10 mg/mL
R1000.I(NP) Male IGS SD Rat Intestinal Microsomes - No PMSF - 10mg/mL - Pooled 0.15mL 10 mg/mL
R1000.IC Male IGS SD Rat Intestinal Cytosol 1mL 4 mg/mL
R1000.IC(NP) Male IGS SD Rat Intestinal Cytosol - No PMSF 1mL 4 mg/mL
R1000.IS9 Male IGS SD Rat Intestinal S9 - 1 mL @ 4mg/mL - Pooled 1mL 4 mg/mL
R1000.IS9(NP) Male IGS SD Rat Intestinal S9 - No PMSF - 4mg/mL - Pooled 1mL 4 mg/mL
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