Treated Animal Liver Subcellular Fractions

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Treating animals with various xenobiotics causes marked induction of liver microsomal CYP levels, which, in long term studies, may be associated with liver or thyroid tumor formation. Sekisui XenoTech provides subcellular fractions from dogs and rats treated with prototypical inducers to serve as positive controls for ex vivo enzyme induction studies.

These products are pooled from many animals to ensure good representation of the inducer and to provide sufficient product availability. The following product information is included with each order of treated animal subcellular fractions.
 
Lot-Specific Information
Cytochrome P450 content
Cytochrome b5 content
NADPH-cytochrome c reductase activity
Activity of the inducible CYP enzyme
Dosing regimen
Animal husbandry conditions

If your study requires treated subcellular fractions not included in our standard product offering, contact one of our product specialists to find out how Sekisui XenoTech’s Custom Products can meet your needs.
  Buy cell and tissue based products
Product Description Volume Protein Concentration Induced CYP
D1063 Pooled clofibric acid-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL CYP4A
D1073 Pooled control, saline-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL Control
D1078 Pooled PB-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL CYP2B
D1083 Pooled B-NF-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL CYP1A
D1095 Pooled rifampin-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL CYP3A
D1098 Pooled control, corn oil-treated Beagle dog liver microsomes, male, 20mg/mL 0.5mL 20 mg/mL Control
P2073 Pooled control, saline-treated Cyno monkey liver microsomes, male, 10 mg/mL 0.5mL 10 mg/mL Control
P2078 Pooled PB-treated Cyno monkey liver microsomes, male, 10mg/mL 0.5mL 10 mg/mL CYP 2A/2B
P2083 Pooled B-NF-treated Cyno monkey liver microsomes, male, 10mg/mL 0.5mL 10 mg/mL CYP1A
P2085 Pooled Pyrazole-treated Cyno monkey liver microsomes, male, 10mg/mL 0.5mL 10 mg/mL CYP2E
P2095 Pooled Rifampin--treated Cyno monkey liver microsomes, male, 10mg/mL 0.5mL 10 mg/mL CYP3A
P2096 Pooled Omeprazole-treated Cyno monkey liver microsomes, male, 10mg/mL 0.5mL 10 mg/mL CYP1A
P2573 Pooled control, saline-treated Cyno monkey liver microsomes, female 10 mg/mL 0.5mL 10 mg/mL Control
P2578 Pooled PB-treated Cyno monkey liver microsomes, female, 10mg/mL 0.5mL 10 mg/mL CYP 2A/2B
P2583 Pooled B-NF-treated Cyno monkey liver microsomes, female, 10mg/mL 0.5mL 10 mg/mL CYP1A
P2585 Pooled Pyrazole-treated Cyno monkey liver microsomes, female, 10mg/mL 0.5mL 10 mg/mL CYP2E
P2595 Pooled Rifampin--treated Cyno monkey liver microsomes, female, 10mg/mL 0.5mL 10 mg/mL CYP3A
P2596 Pooled Omeprazole-treated Cyno monkey liver microsomes, female, 10mg/mL 0.5mL 10 mg/mL CYP1A
R1063 Pooled Male IGS SD Rat Liver Microsomes, Clofibric Acid-Treated, 20mg/mL 0.5mL 20 mg/mL CYP4A
R1073 Pooled Male IGS SD Rat Liver Microsomes, 20mg/mL, Saline-Treated Control 0.5mL 20 mg/mL Control
R1078 Pooled Male IGS SD Rat Liver Microsomes, PB-Treated 0.5 mL @ 20mg/mL 0.5mL 20 mg/mL CYP2B
R1081 Male IGS SD Rat Liver Microsomes, Pb-Treated 20mg/mL 0.5mL 20 mg/mL CYP 1A/2B
R1081.S9 Male IGS SD Rat Liver S9, PB-Treated 20mg/mL 1mL 20 mg/mL CYP 1A/2B
R1083 Male IGS SD Rat Liver Microsomes, BNF-Treated 20mg/mL 0.5mL 20 mg/mL CYP1A
R1088 Male IGS SD Rat Liver Microsomes, Isoniazid-Treated 20mg/mL 0.5mL 20 mg/mL CYP2E
R1093 Male IGS SD Rat Liver Microsomes, Dex-Treated 20mg/mL 0.5mL 20 mg/mL CYP3A
R1098 Male IGS SD Rat Liver Microsomes, Corn Oil-Treated 20mg/mL Control 0.5mL 20 mg/mL Control
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