Evaluation method for mitochondrial toxicity using Crabtree effect

Evaluation method for mitochondrial toxicity using Crabtree effect

Published:  10/15/2016 1:14:06 PM

Mitochondria plays a crucial role in living organisms, one of which being the synthesis of ATP. Mitochondrial toxicity is widely tested as part of the compound’s toxicity screening and within FDA’s registered drug with a ‘black box warning’, roughly 80% of drugs are reported with mitochondrial toxicity. The aim of this research is to devise a simple method to evaluate mitochondrial toxicity across different toxicological mechanisms using human liver derived cells.

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