Enzyme Induction

The metabolic clearance of a drug (victim) can be increased and its efficacy reduced, if it is co-administered with a second drug (perpetrator) that up-regulates (or induces / activates) the enzyme responsible for the victim drug's metabolism. The increased clearance may compromise the therapeutic effectiveness or safety of the victim drug. As such, the FDA and other regulatory agencies recognize enzyme induction (also known as enzyme activation) as a potential cause of drug-drug interactions. Sekisui XenoTech offers well-designed Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) in vitro studies that meet or exceed the FDA and/or EMA's latest regulatory guidance for enzyme induction.

Sekisui XenoTech's Enzyme Induction group offers the following services that can be tailored to the specific needs of the client and/or the drug in question:

Enzyme Induction Automation and Analysis

  • Validated qRT-PCR methods
  • Tecan liquid handling systems or manual incubations available
  • Validated LC-MS/MS methods
  • High throughput Shimadzu autosamplers
  • Deuterated internal standards (all CYPs and most UGTs)
  • Automated data retrieval and processing
  • Comprehensive, publication-quality reports
  • Available as GLP or non-GLP
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