In Vitro Discovery Plus Induction (Screening)

Overview

Sekisui XenoTech's Discovery Plus Induction studies utilize cryopreserved hepatocytes to control timelines for faster turnaround from initiation to data and repeatability within Sekisui XenoTech's expansive lots. Our 96-well plate format allows for flexibility between compounds and concentrations, giving you full control of your plate combination(s).

Induction Screening General Study Design

• Cryopreserved hepatocytes (1 donor) plated in a 96-well format

• Cellular morphology and confluency assessment
• mRNA endpoint

• Up to 9 compounds at 3 concentrations
• Tabular and graphical summary
• Non-GLP

Optional Extras

• Cryopreserved hepatocytes (1 to 3 donors) plated in a 96-well format
• CYP Enzymatic (substrate cocktail) and mRNA endpoints

• EC₅₀ / E_max data generation
• Up to 5 compounds at 5 concentrations

   

How Can We Help You?

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In vitro CYP Induction (Definitive)
In vitro UGT Induction (Definitive)
Ex vivo CYP and UGT Enzyme Induction
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• Analytical Services
  • Metabolite ID & Characterization
  • Small-molecule bioanalysis
• Biologic Services
• Consulting
• Discovery Plus Screening Suite
  • Plasma Protein Binding
  • Metabolic Stability
  • CYP Inhibition
  • Enzyme Induction
  • Drug Transporter Inhibition
  • Cell-Based Permeability
• Drug Metabolism
  • Metabolic Stability
  • Metabolite ID & Characterization
    • Metabolite Production
  • Plasma Protein & Covalent Binding
  • Reaction Phenotyping
  • Species Comparison
  • Non-CYP Metabolism
• Drug Transporters
  • ABC (Efflux) Transporters
    • Transwell Assay Design
    • Vesicle Assay Design
  • SLC (Uptake) Transporters
    • Uptake Assay Design
  • Clinically Relevant Transporter DDIs
• Enzyme Induction
  • In Vitro CYP Induction (Definitive)
  • In Vitro UGT Induction (Definitive)
  • In Vitro Discovery Plus Induction (Screening)
  • Ex Vivo CYP and UGT Enzyme Induction
  • Cytotoxicity
• Enzyme Inhibition
  • CYP Inhibition
    • Follow-up Studies
  • Discovery Plus Inhibition Screening
  • UGT Inhibition
• In Vivo ADME
  • Pharmacokinetics
  • Radio-Labeled Synthesis
    • Metabolite Production
  • Whole-Body Autoradiography
• Lysosomal Trapping
• Pharmacology / Receptor Binding
  • RadioReceptor Assay (RRA)
• Protein Binding
• API Manufacturing
• Services Catalog