In Vitro Discovery Plus Induction (Screening)

Overview

Sekisui XenoTech's Discovery Plus Induction studies utilize cryopreserved hepatocytes to control timelines for faster turnaround from initiation to data and repeatability within Sekisui XenoTech's expansive lots. Our 96-well plate format allows for flexibility between compounds and concentrations, giving you full control of your plate combination(s).

Induction Screening General Study Design
  • Cryopreserved hepatocytes (1 donor) plated in a 96-well format
  • Cellular morphology and confluency assessment
  • mRNA endpoint
  • Up to 9 compounds at 3 concentrations
  • Tabular and graphical summary
  • Non-GLP

Optional Extras
  • Cryopreserved hepatocytes (1 to 3 donors) plated in a 96-well format
  • CYP Enzymatic (substrate cocktail) and mRNA endpoints
  • EC50 / Emax data generation
  • Up to 5 compounds at 5 concentrations
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In vitro CYP Induction (Definitive)
In vitro UGT Induction (Definitive)
Ex vivo CYP and UGT Enzyme Induction
Cytotoxicity
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