To make room for our expanding range of cell and tissue-based products, we’re clearing out a selection of lots from many of our hepatocyte, microsome, cytosol and S9 products!
Discounted Human Hepatocytes for In Vitro DMPK Assays in Drug Development
Use promo code “CLEARANCE” to save 40% off* any of the following human hepatocyte lots:
*May not be available in all areas. Discount applies to standard list price for your area and cannot be combined with other offers or discounts.
Human Hepatocytes: The Gold Standard for In Vitro Drug Metabolism Assays
Primary human hepatocytes are often referred to as the “gold standard” for in vitro hepatic assays. The majority of hepatocyte-specific cellular function can be maintained in culture, which makes them the best model for replicating hepatic function in vitro, e.g. xenobiotic metabolism, liver toxicity, cell biology, and host-pathogen interactions.
In drug development, hepatocytes are best suited for metabolism, clearance, uptake, hepatotoxicity, and drug-drug interaction assays. They are a highly effective model because most drug metabolizing-enzymes are abundantly found in this particular type of cell in the human liver, a primary site of drug metabolism.
Lots are accompanied by data sheets with important information about donors and enzyme characterization. We perform tests on each lot to characterize for activity of the following enzymes:
|Enzyme||Marker Substrate Reaction|
*Uptake transporter characterization available on specified lots
Thawing & Plating Cryopreserved Hepatocytes:
Check out the following demos to learn proper thawing and plating procedures for any of our cryopreserved human or animal hepatocytes.