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Webinars

RI-ADE ADME 101: Non-clinical pharmacokinetics studies using radio-labeled compounds

Presenter: Satoshi Ito, Drug Development Solutions Center ADME Group Manager, Sekisui Medical Radio-labeled compounds can be used to provide important information during the drug development process....

Dual-Hybridization PALSAR (Probe Alternation Link Self-Assembly Reaction) Technology Introduction

Presenter: Yuya Ono, MSc, MBA. Sekisui Medical, Co. Ltd. The quantitative bioanalysis of oligonucleotide therapeutics is mainly conducted with LC-MS/MS and hybridization-based ligand binding assays (LBA)....

Design Intricacies and Decision-Making Strategy for Drug-Drug Interaction Studies

Presenter: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at XenoTech Conducting in vitro ADME drug-drug interaction (DDI) studies early on in the drug...

Highlights of the In Vitro Sections of the Draft ICH Drug Interaction Studies Guideline and Comparison with Current Guidance

Presenter: Brian Ogilvie, Ph.D, Vice President of Scientific Consulting at XenoTech In June 2022, the ICH released the first draft of its harmonized Drug Interaction Studies Guideline (M12). The...

Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary

Presenter: Griff Humphreys, Ph.D, XenoTech Consultant Recorded keynote presentation from XenoTech’s 2022 Seminar Series. Learn about what this important section consists of, the studies that...

Role of Sulfotransferases (SULTs) in Drug Metabolism and Potential for Drug-Drug Interactions

Presenter: Maciej Czerwinski, Ph.D., XenoTech Director of Scientific Consulting Abstract: Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested...

Webinar: Bridging In Vitro Data to Clinical Outcomes with MetID

Presenters: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at XenoTech and Heather Heading, Director of LCMS at Agilex Biolabs Abstract: Profiling, characterising,...

ADME 101: Microsomal Protein Binding of Drugs

Presenter: Kusum Parikh, MBBS, PhD, XenoTech Senior Scientist in Program Oversight Abstract: Regulatory guidance states that drug developers should correct for nonspecific binding in microsomes...

Reactive Metabolite Detection Studies: Cysteine Trapping

Presenter: Miki Fujishima, Manager in Business Development at the Drug Development Solutions Center in Tokai, Japan. Abstract: Drug-induced liver injury (DILI) is caused by various...

Role of UDP-Glucuronosyltransferases (UGTs) in Drug Metabolism and Drug-Drug Interactions

Presenter: Maciej Czerwinski, Ph.D., XenoTech Director of Scientific Consulting Abstract: The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and...

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