Pharmacokinetics

Overview

Pharmacokinetics (PK) describes the relationship between drug concentration and time following administration of a test article into an organism. PK is the study of Absorption, Distribution, Metabolism and Excretion (ADME).

Sekisui XenoTech offers PK studies using unlabeled test compound to assist your drug development plan.

Administration routes*
Oral, intravenous, continuous intravenous, transdermal, subcutaneous, intramuscular, intratracheal, instillation, intrarectal and introduodenal.
* Single and multiple dosing available

Species
Mouse (including chimeric mice), rat, guinea pig, rabbit, minipig, dog and monkey. Various animal disease model and XenoGraft model pharmacokinetic studies are also available.

Matrices
Animals
  • Plasma, serum, whole blood, urine, brain, skin, synovial membrane and cerebrospinal fluid (CSF)

Humans
  • Plasma, serum, urine and horny layer of skin

Deliverables
Cmax, tmax, t1/2, AUC0-t, AUCinf, CLtot, Vdss, BA

Analytical Technique
LC-MS/MS system
  • Qtrap 5500 (AB Sciex)
  • API 5000 (AB Sciex)
  • API 4000 (AB Sciex)
  • Qtrap 4000 (AB Sciex)
  • LTQ (Thermo)

HPLC
  • LC10A (Shimadzu)
  • LC10Avp (Shimadzu)
  • LD20AD (Shimadzu)

UPLC
  • Acquity™ UPLC (Waters)

Immunoassay system
  • EnVision (PerkinElmer)
  • Mithras LB940-BA (Berthold Technologies)
  • SECTOR Imager 6000 (Meso Scale Discovery)
  • Bio-Plex 200 (Bio-Rad)
  • Simoa HD-1 analyzer (Quanterix)
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<< In vivo ADME
Radio-Labeled Synthesis
Whole-Body Autoradiography
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