Skip to content
Molecules
SEKISUI XenoTech DD Blog Logo

Author: Dr. Chris Bohl

How to Choose the Right Test Systems for Your DMPK Studies

Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...

Cell Handling & Media Selection for Best Results in Hepatocyte Assays

Getting reliable, reproducible results from studies using hepatocytes as a model system for drug metabolism is in part dependent on how well...

Choosing a Relevant Small Animal Model for Pharmacokinetic or Toxicity Studies

Choosing the most suitable small animal model is crucial for pharmacokinetic and/or toxicology studies in order to get usable, relevant data. Due to potential...

What To Do with Microsome Stable Low Turnover Compounds

Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol) can be a challenge for ADME scientists. These in...

Considerations When Studying Esterase Activities in the Intestine

The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...

New Lysosome Catabolism Protocol and Tech Tips

A new guide outlining our IgG Catabolism Protocol as well as Lysosome and Tritosome Technical Tips is now available for those evaluating lysosomal stability...

SEKISUI XenoTech Standardizes Lysosomal Test Systems for Biopharmaceutical Development

Before releasing these test systems, there was not a high quality, specific, relevant, easy and ready to use, in vitro test system to...

Why Switch to Hepatocyte Pellets?

You may have heard about the patented CryostaX® format of hepatocyte pellets, but do you know why SEKISUI XenoTech and countless other researchers have made…

Timing of In Vitro Studies: Early, Thorough ADME for Your Compound’s Success

Beyond the need for evidence that a drug works, Food and Drug Administration (FDA) and other regulatory bodies around the...

Disease-State Test Systems

SEKISUI XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years...

No-Cost, On-Demand Primary Human Hepatocyte Pooling Using CryostaX Pellets

CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows scientists to easily pool primary...

Maximize Metabolic Activities by Limiting Hepatocyte Cryoinjury

Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. Traditional pooling methods require cells to undergo two separate cryopreservation...

No More Water Baths! Simplify Hepatocyte Thaws and Eliminate Contamination

SEKISUI XenoTech has patented technology that eliminates the need for the water baths that are traditionally required to thaw cryopreserved hepatocytes. By removing...

Building a reputation for excellence

We are proud to have some of the brightest minds in DDI & DMPK research in our labs. Browse our new Meet Our Experts page where you can find bios for some of our most seasoned scientists working on both Contract Research & Test Systems teams.

Team of DMPK researchers

Read more about the research performed at SEKIUI XenoTech

Access ADME™ is our all-inclusive repository for scientific resources. Find scientific posters, publications, blog posts, webinars and more relating to ADME/DMPK, drug-drug interactions and other studies.

Access ADME