Scientific Posters
The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes
Full Title The effect of multiple cryopreservation cycles on drug-metabolizing enzymes in human hepatocytes Abstract Cryopreserved hepatocytes provide a convenient in vitro test system to...
Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to Underestimation of the Shifted IC50 Value
Full Title Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to...
Induction of Liver and Intestinal Cytochrome P450 (CYP) Enzymes in Male and Female Cynomolgus Monkey
Full Title Induction of Liver and Intestinal Cytochrome P450 (CYP) Enzymes in Male and Female Cynomolgus Monkey Abstract The objective of the present study was...
Effects of Gender, Age and Ethnicity on Human Cytochrome P450 Activity
Full Title Effects of Gender, Age and Ethnicity on Human Cytochrome P450 Activity Abstract It has been well documented that the expression of CYP enzymes...
Microsomes and S9 Prepared from Renal Tissue Yield High CYP, FMO and UGT Activities that are Stable…
Presented at the JSSX/ISSX Meeting, Maui, HI October 2005. Abstracts published in Drug Metabolism Reviews, Vol. 37, Supplement 2 Full Title Microsomes and S9 prepared...
Cytochrome P450 3A4 and 1A2 Induction in Immortalized and Primary Cultures of Human Hepatocytes
Full Title Cytochrome P450 3A4 and 1A2 Induction in the Immortalized Hepatocyte Line, Fa2N-4, and Comparison with Primary Cultures of Human Hepatocytes Abstract Primary cultures...
Microsomes Prepared from Eluted Enterocytes Yield High Cytochrome P450 and UGT Activities that are…
Full Title Microsomes Prepared from Eluted Enterocytes Yield High Cytochrome P450 and UGT Activities that are Stable over Multiple Freeze/Thaw Cycles Abstract Enterocytes in the...
The Use of Immortalized Hepatocytes in Induction Studies
Abstract Primary cultures of human hepatocytes are widely used to evaluate the cytochrome P450 (CYP) enzyme-inducing potential and/or toxicity of drug candidates. However, the availability...