Drug Transporters

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of endogenous and exogenous compounds, inasmuch as transporter-mediated drug-drug interactions (DDI) are associated with potential toxicological and pharmacological consequences. As evidenced in numerous publications, the effects of transporters on the pharmacokinetics of several drugs, and associated DDI, have been reported. Consequently, recent guidance documents released by the US FDA, European Medicines Agency (EMA) and Japanese Pharmaceuticals and Medical Devices Agency (PMDA) emphasize the importance of evaluating the potential of new drug candidates for transporter-mediated DDI with a determination of victim (substrate) and perpetrator (inhibition) potential.

Sekisui XenoTech performs in vitro transporter studies to determine if compounds are substrates or inhibitors of clinically-relevant transporters with validated, and industry accepted, test systems. In addition to a dedicated drug transport team, XenoTech employs an experienced analytical department with capabilities to conduct studies with labeled or unlabeled drug candidates, a Quality Assurance Department to oversee GLP studies and a Knowledge Management Group to facilitate and expedite production of high quality reports.

Features of Sekisui XenoTech's Transporter Studies:

  • The most extensive selection of transporters and assays available in the world
  • Multiple test systems for the major transporters, from membranes to in vivo models
  • Expert guidance for compound development custom-designed for your needs
  • Communication and review of all study materials performed by a transporter specialist
  • In-house LC-MS/MS (Analytical), Quality Assurance and Knowledge Management Groups ensure quality data and reporting with fast turnaround times
  • GLP and non-GLP services available
  • Screening services available

View our Full Transporter Portfolio

Efflux Transporter Services

Uptake Transporter Services

Clinically Relevant DDIs
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Helpful Transporter Links

FDA Guidance
Guidance for Industry Drug Interaction Studies - Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations

EMA Guidance
Guideline on the Investigation of Drug Interactions

2013 ITC Publications
July 2013 issue of Clinical Pharmacology and Therapeutics

2010 ITC Publication
Membrane Transporters in Drug Development

UCSF-FDA Transportal

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